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Antonino Glaviano, Aaron Song Chuan Foo, Hiu Yan Lam, Kenneth Chun-Yong Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G Nair, Pooyan Makvandi, Birgit Geoerger and 17 more
The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions with several other signaling pathways, and dysregulation of signal transduction can predispose to cancer development. The PAM axis is the most frequently activated signaling pathway in human cancer and is often implicated in resistance to anticancer therapies. Dysfunction of components of this pathway such as hyperactivity of PI3K, loss of function of PTEN, and gain-of-function of AKT, are notorious drivers of treatment resistance and disease progression in cancer. In this review we highlight the major dysregulations in the PAM signaling pathway in cancer, and discuss the results of PI3K, AKT and mTOR inhibitors as monotherapy and in co-administation with other antineoplastic agents in clinical trials as a strategy for overcoming treatment resistance. Finally, the major mechanisms of resistance to PAM signaling targeted therapies, including PAM signaling in immunology and immunotherapies are also discussed.
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Glaviano, A., Foo, A. S. C., Lam, H. Y., Yap, K. C.-Y., Jacot, W., Jones, R. H., Eng, H., Nair, M. G., Makvandi, P., Geoerger, B., Kulke, M. H., Baird, R. D., Prabhu, J. S., Carbone, D., Pecoraro, C., Teh, D. B. L., Sethi, G., Cavalieri, V., Lin, K., … Kumar, A. P. (2023). PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular Cancer, 22(1), 138. https://doi.org/10.1186/s12943-023-01827-6
Glaviano, Antonino, et al. "PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer." Molecular Cancer, vol. 22, no. 1, 2023, pp. 138, https://doi.org/10.1186/s12943-023-01827-6.
Glaviano, Antonino, Aaron Song Chuan Foo, Hiu Yan Lam, Kenneth Chun-Yong Yap, William Jacot, Robert H. Jones, Huiyan Eng, et al. "PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer." Molecular Cancer 22, no. 1 (2023): 138. https://doi.org/10.1186/s12943-023-01827-6.
Glaviano A., Foo A. S. C., Lam H. Y. [и др.] PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer // Molecular Cancer. — 2023. — Vol. 22, № 1. — P. 138. — URL: https://doi.org/10.1186/s12943-023-01827-6
@article{glaviano2023pikaktmtor,
title = {{PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer}},
author = {Antonino Glaviano and Aaron Song Chuan Foo and Hiu Yan Lam and Kenneth Chun-Yong Yap and William Jacot and Robert H. Jones and Huiyan Eng and Madhumathy G Nair and Pooyan Makvandi and Birgit Geoerger and Matthew H. Kulke and Richard D. Baird and Jyothi S. Prabhu and Daniela Carbone and Camilla Pecoraro and Daniel Boon Loong Teh and Gautam Sethi and Vincenzo Cavalieri and Kevin Lin and Nathalie Javidi‐Sharifi and Eneda Toska and Matthew Steven Davids and Jennifer R. Brown and Patrizia Diana and Justin Stebbing and David A. Fruman and Alan Prem Kumar},
journal = {Molecular Cancer},
year = {2023},
volume = {22},
number = {1},
pages = {138},
doi = {10.1186/s12943-023-01827-6},
url = {https://doi.org/10.1186/s12943-023-01827-6}
}TY - JOUR AU - Glaviano, Antonino AU - Foo, Aaron Song Chuan AU - Lam, Hiu Yan AU - Yap, Kenneth Chun-Yong AU - Jacot, William AU - Jones, Robert H. AU - Eng, Huiyan AU - Nair, Madhumathy G AU - Makvandi, Pooyan AU - Geoerger, Birgit AU - Kulke, Matthew H. AU - Baird, Richard D. AU - Prabhu, Jyothi S. AU - Carbone, Daniela AU - Pecoraro, Camilla AU - Teh, Daniel Boon Loong AU - Sethi, Gautam AU - Cavalieri, Vincenzo AU - Lin, Kevin AU - Javidi‐Sharifi, Nathalie AU - Toska, Eneda AU - Davids, Matthew Steven AU - Brown, Jennifer R. AU - Diana, Patrizia AU - Stebbing, Justin AU - Fruman, David A. AU - Kumar, Alan Prem TI - PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer JO - Molecular Cancer VL - 22 IS - 1 SP - 138 PY - 2023 DA - 2023/08/18 DO - 10.1186/s12943-023-01827-6 UR - https://doi.org/10.1186/s12943-023-01827-6 ER -
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