One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Deepak A. Subramanian, Róbert Langer, Giovanni Traverso
Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intestinal absorption is rapid clearance of the drug and the drug delivery system from the gastrointestinal (GI) tract. To address this issue, researchers have investigated using GI mucus to help maximize the pharmacokinetics of the therapeutic; while mucus can act as a barrier to effective oral delivery, it can also be used as an anchoring mechanism to improve intestinal residence. Nano-drug delivery systems that use materials which can interact with the mucus layers in the GI tract can enable longer residence time, improving the efficacy of oral drug delivery. This review examines the properties and function of mucus in the GI tract, as well as diseases that alter mucus. Three broad classes of mucus-interacting systems are discussed: mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems. For each class of system, the basis for mucus interaction is presented, and examples of materials that inform the development of these systems are discussed and reviewed. Finally, a list of FDA-approved mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems is reviewed. In summary, this review highlights the progress made in developing mucus-interacting systems, both at a research-scale and commercial-scale level, and describes the theoretical basis for each type of system.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Subramanian, D. A., Langer, R., & Traverso, G. (2022). Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems. Journal of Nanobiotechnology, 20(1), 362. https://doi.org/10.1186/s12951-022-01539-x
Subramanian, Deepak A., et al. "Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems." Journal of Nanobiotechnology, vol. 20, no. 1, 2022, pp. 362, https://doi.org/10.1186/s12951-022-01539-x.
Subramanian, Deepak A., Róbert Langer, and Giovanni Traverso. "Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems." Journal of Nanobiotechnology 20, no. 1 (2022): 362. https://doi.org/10.1186/s12951-022-01539-x.
Subramanian D. A., Langer R., Traverso G. Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems // Journal of Nanobiotechnology. — 2022. — Vol. 20, № 1. — P. 362. — URL: https://doi.org/10.1186/s12951-022-01539-x
@article{subramanian2022mucus,
title = {{Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems}},
author = {Deepak A. Subramanian and Róbert Langer and Giovanni Traverso},
journal = {Journal of Nanobiotechnology},
year = {2022},
volume = {20},
number = {1},
pages = {362},
doi = {10.1186/s12951-022-01539-x},
url = {https://doi.org/10.1186/s12951-022-01539-x}
}TY - JOUR AU - Subramanian, Deepak A. AU - Langer, Róbert AU - Traverso, Giovanni TI - Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems JO - Journal of Nanobiotechnology VL - 20 IS - 1 SP - 362 PY - 2022 DA - 2022/08/06 DO - 10.1186/s12951-022-01539-x UR - https://doi.org/10.1186/s12951-022-01539-x ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.