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Sonam Gurung, Dany P.B. Perocheau, Loukia Touramanidou, Julien Baruteau
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors. Exosomes are small extracellular vesicles secreted by all cell types playing intercellular communication roles in health and disease by transferring cellular cargoes such as functional proteins, metabolites and nucleic acids to recipient cells. An in-depth understanding of exosome biology is therefore essential to ensure clinical development of exosome based investigational therapeutic products. Here we summarise the most up-to-date knowkedge about the complex biological journey of exosomes from biogenesis and secretion, transport and uptake to their intracellular signalling. We delineate the major pathways and molecular players that influence each step of exosome physiology, highlighting the routes of interest, which will be of benefit to exosome manipulation and engineering. We highlight the main controversies in the field of exosome research: their adequate definition, characterisation and biogenesis at plasma membrane. We also delineate the most common identified pitfalls affecting exosome research and development. Unravelling exosome physiology is key to their ultimate progression towards clinical applications. Video Abstract.
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Gurung, S., Perocheau, D. P., Touramanidou, L., & Baruteau, J. (2021). The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Communication and Signaling, 19(1), 47. https://doi.org/10.1186/s12964-021-00730-1
Gurung, Sonam, et al. "The exosome journey: from biogenesis to uptake and intracellular signalling." Cell Communication and Signaling, vol. 19, no. 1, 2021, pp. 47, https://doi.org/10.1186/s12964-021-00730-1.
Gurung, Sonam, Dany P.B. Perocheau, Loukia Touramanidou, and Julien Baruteau. "The exosome journey: from biogenesis to uptake and intracellular signalling." Cell Communication and Signaling 19, no. 1 (2021): 47. https://doi.org/10.1186/s12964-021-00730-1.
Gurung S., Perocheau D. P., Touramanidou L. [и др.] The exosome journey: from biogenesis to uptake and intracellular signalling // Cell Communication and Signaling. — 2021. — Vol. 19, № 1. — P. 47. — URL: https://doi.org/10.1186/s12964-021-00730-1
@article{gurung2021exosome,
title = {{The exosome journey: from biogenesis to uptake and intracellular signalling}},
author = {Sonam Gurung and Dany P.B. Perocheau and Loukia Touramanidou and Julien Baruteau},
journal = {Cell Communication and Signaling},
year = {2021},
volume = {19},
number = {1},
pages = {47},
doi = {10.1186/s12964-021-00730-1},
url = {https://doi.org/10.1186/s12964-021-00730-1}
}TY - JOUR AU - Gurung, Sonam AU - Perocheau, Dany P.B. AU - Touramanidou, Loukia AU - Baruteau, Julien TI - The exosome journey: from biogenesis to uptake and intracellular signalling JO - Cell Communication and Signaling VL - 19 IS - 1 SP - 47 PY - 2021 DA - 2021/04/23 DO - 10.1186/s12964-021-00730-1 UR - https://doi.org/10.1186/s12964-021-00730-1 ER -
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