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Hyojin Kim, Hyemin Kim, Jeong‐Hyung Lee, Cheol Hwangbo
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane's surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, TLR4 activates transcription factors NF-κB and AP-1, thereby facilitating the upregulation of pro-inflammatory cytokines. Another adapter protein linked to TLR4, known as TRIF, autonomously propagates signaling pathways, resulting in heightened interferon expression. Recently, TLR4 has garnered attention as a significant factor in the regulation of symptoms in aging-related disorders. The persistent inflammatory response triggered by TLR4 contributes to the onset and exacerbation of these disorders. In addition, alterations in TLR4 expression levels play a pivotal role in modifying the manifestations of age-related diseases. In this review, we aim to consolidate the impact of TLR4 on cellular senescence and aging-related ailments, highlighting the potential of TLR4 as a novel therapeutic target that extends beyond immune responses.
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Kim, H., Kim, H., Lee, J., & Hwangbo, C. (2023). Toll-like receptor 4 (TLR4): new insight immune and aging. Immunity & Ageing, 20(1), 67. https://doi.org/10.1186/s12979-023-00383-3
Kim, Hyojin, et al. "Toll-like receptor 4 (TLR4): new insight immune and aging." Immunity & Ageing, vol. 20, no. 1, 2023, pp. 67, https://doi.org/10.1186/s12979-023-00383-3.
Kim, Hyojin, Hyemin Kim, Jeong‐Hyung Lee, and Cheol Hwangbo. "Toll-like receptor 4 (TLR4): new insight immune and aging." Immunity & Ageing 20, no. 1 (2023): 67. https://doi.org/10.1186/s12979-023-00383-3.
Kim H., Kim H., Lee J. [и др.] Toll-like receptor 4 (TLR4): new insight immune and aging // Immunity & Ageing. — 2023. — Vol. 20, № 1. — P. 67. — URL: https://doi.org/10.1186/s12979-023-00383-3
@article{kim2023tolllike,
title = {{Toll-like receptor 4 (TLR4): new insight immune and aging}},
author = {Hyojin Kim and Hyemin Kim and Jeong‐Hyung Lee and Cheol Hwangbo},
journal = {Immunity \& Ageing},
year = {2023},
volume = {20},
number = {1},
pages = {67},
doi = {10.1186/s12979-023-00383-3},
url = {https://doi.org/10.1186/s12979-023-00383-3}
}TY - JOUR AU - Kim, Hyojin AU - Kim, Hyemin AU - Lee, Jeong‐Hyung AU - Hwangbo, Cheol TI - Toll-like receptor 4 (TLR4): new insight immune and aging JO - Immunity & Ageing VL - 20 IS - 1 SP - 67 PY - 2023 DA - 2023/11/24 DO - 10.1186/s12979-023-00383-3 UR - https://doi.org/10.1186/s12979-023-00383-3 ER -
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