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Franziska Böttger, Andrea Vallés‐Martí, Loraine Cahn, Connie R. Jiménez
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer agent when administered intravenously and in high doses (high-dose IVC). Early phase clinical trials have confirmed safety and indicated efficacy of IVC in eradicating tumour cells of various cancer types. In recent years, the multi-targeting effects of vitamin C were unravelled, demonstrating a role as cancer-specific, pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator, reversing epithelial-to-mesenchymal transition, inhibiting hypoxia and oncogenic kinase signalling and boosting immune response. Moreover, high-dose IVC is powerful as an adjuvant treatment for cancer, acting synergistically with many standard (chemo-) therapies, as well as a method for mitigating the toxic side-effects of chemotherapy. Despite the rationale and ample evidence, strong clinical data and phase III studies are lacking. Therefore, there is a need for more extensive awareness of the use of this highly promising, non-toxic cancer treatment in the clinical setting. In this review, we provide an elaborate overview of pre-clinical and clinical studies using high-dose IVC as anti-cancer agent, as well as a detailed evaluation of the main known molecular mechanisms involved. A special focus is put on global molecular profiling studies in this respect. In addition, an outlook on future implications of high-dose vitamin C in cancer treatment is presented and recommendations for further research are discussed.
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Böttger, F., Vallés‐Martí, A., Cahn, L., & Jiménez, C. R. (2021). High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 343. https://doi.org/10.1186/s13046-021-02134-y
Böttger, Franziska, et al. "High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer." Journal of Experimental & Clinical Cancer Research, vol. 40, no. 1, 2021, pp. 343, https://doi.org/10.1186/s13046-021-02134-y.
Böttger, Franziska, Andrea Vallés‐Martí, Loraine Cahn, and Connie R. Jiménez. "High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer." Journal of Experimental & Clinical Cancer Research 40, no. 1 (2021): 343. https://doi.org/10.1186/s13046-021-02134-y.
Böttger F., Vallés‐Martí A., Cahn L. [и др.] High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer // Journal of Experimental & Clinical Cancer Research. — 2021. — Vol. 40, № 1. — P. 343. — URL: https://doi.org/10.1186/s13046-021-02134-y
@article{bottger2021highdose,
title = {{High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer}},
author = {Franziska Böttger and Andrea Vallés‐Martí and Loraine Cahn and Connie R. Jiménez},
journal = {Journal of Experimental \& Clinical Cancer Research},
year = {2021},
volume = {40},
number = {1},
pages = {343},
doi = {10.1186/s13046-021-02134-y},
url = {https://doi.org/10.1186/s13046-021-02134-y}
}TY - JOUR AU - Böttger, Franziska AU - Vallés‐Martí, Andrea AU - Cahn, Loraine AU - Jiménez, Connie R. TI - High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer JO - Journal of Experimental & Clinical Cancer Research VL - 40 IS - 1 SP - 343 PY - 2021 DA - 2021/10/30 DO - 10.1186/s13046-021-02134-y UR - https://doi.org/10.1186/s13046-021-02134-y ER -
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