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Jing Zhang, Xin Rao, Yiming Li, Yuan Zhu, Fang Liu, Guangling Guo, Guoshi Luo, Zhongji Meng, Daniel De Backer, Hui Xiang, Zhiyong Peng
Background Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe COVID-19. Methods This randomized, controlled, clinical trial was performed at 3 hospitals in Hubei, China. Patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the ICU were randomly assigned in as 1:1 ratio to either the high-dose intravenous vitamin C (HDIVC) or the placebo. HDIVC group received 12 g of vitamin C/50 ml every 12 h for 7 days at a rate of 12 ml/hour, and the placebo group received bacteriostatic water for injection in the same way within 48 h of arrival to ICU. The primary outcome was invasive mechanical ventilation-free days in 28 days (IMVFD28). Secondary outcomes were 28-day mortality, organ failure (Sequential Organ Failure Assessment (SOFA) score), and inflammation progression (interleukin-6). Results Only 56 critical COVID-19 patients were ultimately recruited due to the early control of the outbreak. There was no difference in IMVFD28 between two groups (26.0 [9.0–28.0] in HDIVC vs 22.0 [8.50–28.0] in control, p = 0.57). HDIVC failed to reduce 28-day mortality ( P = 0.27). During the 7-day treatment period, patients in the HDIVC group had a steady rise in the PaO 2 /FiO 2 (day 7: 229 vs. 151 mmHg, 95% CI 33 to 122, P = 0.01), which was not observed in the control group. IL-6 in the HDIVC group was lower than that in the control group (19.42 vs. 158.00; 95% CI -301.72 to -29.79; P = 0.04) on day 7. Conclusion This pilot trial showed that HDIVC failed to improve IMVFD28, but might show a potential signal of benefit in oxygenation for critically ill patients with COVID-19 improving PaO2/FiO2 even though.
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Zhang, J., Rao, X., Li, Y., Zhu, Y., Liu, F., Guo, G., Luo, G., Meng, Z., Backer, D. D., Xiang, H., & Peng, Z. (2021). Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Annals of Intensive Care, 11(1), 5. https://doi.org/10.1186/s13613-020-00792-3
Zhang, Jing, et al. "Pilot trial of high-dose vitamin C in critically ill COVID-19 patients." Annals of Intensive Care, vol. 11, no. 1, 2021, pp. 5, https://doi.org/10.1186/s13613-020-00792-3.
Zhang, Jing, Xin Rao, Yiming Li, Yuan Zhu, Fang Liu, Guangling Guo, Guoshi Luo, et al. "Pilot trial of high-dose vitamin C in critically ill COVID-19 patients." Annals of Intensive Care 11, no. 1 (2021): 5. https://doi.org/10.1186/s13613-020-00792-3.
Zhang J., Rao X., Li Y. [и др.] Pilot trial of high-dose vitamin C in critically ill COVID-19 patients // Annals of Intensive Care. — 2021. — Vol. 11, № 1. — P. 5. — URL: https://doi.org/10.1186/s13613-020-00792-3
@article{zhang2021pilot,
title = {{Pilot trial of high-dose vitamin C in critically ill COVID-19 patients}},
author = {Jing Zhang and Xin Rao and Yiming Li and Yuan Zhu and Fang Liu and Guangling Guo and Guoshi Luo and Zhongji Meng and Daniel De Backer and Hui Xiang and Zhiyong Peng},
journal = {Annals of Intensive Care},
year = {2021},
volume = {11},
number = {1},
pages = {5},
doi = {10.1186/s13613-020-00792-3},
url = {https://doi.org/10.1186/s13613-020-00792-3}
}TY - JOUR AU - Zhang, Jing AU - Rao, Xin AU - Li, Yiming AU - Zhu, Yuan AU - Liu, Fang AU - Guo, Guangling AU - Luo, Guoshi AU - Meng, Zhongji AU - Backer, Daniel De AU - Xiang, Hui AU - Peng, Zhiyong TI - Pilot trial of high-dose vitamin C in critically ill COVID-19 patients JO - Annals of Intensive Care VL - 11 IS - 1 SP - 5 PY - 2021 DA - 2021/01/09 DO - 10.1186/s13613-020-00792-3 UR - https://doi.org/10.1186/s13613-020-00792-3 ER -
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