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Yanyu Zhang, Yu‐Feng Huang, Jie Liang, Hua Zhou
BACKGROUND: Up-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long experimental period (20-42 days). To improve UDP, an improved UDP method (iUDP) was developed by shortening observation time between sequence dosages. The aim of this study was to test the reliability of iUDP to provide a reliable method for the acute toxicity measurement of valuable or minor amount compounds. METHODS: ) of nicotine, sinomenine hydrochloride and berberine hydrochloride were measured both by iUDP and modified Karber method (mKM). RESULTS: of the three alkaloids measured by mKM with 240 mice were 22.99 ± 3.01, 456.56 ± 53.38, 2825.53 ± 1212.92 mg/kg, respectively. The average time consumed by the two methods were 22 days and 14 days respectively. Total grams of the alkaloids used by the two methods were 0.0082 and 0.0673 (nicotine), 0.114 and 1.24 (sinomenine hydrochloride), 1.9 and 12.7 (berberine hydrochloride). CONCLUSION: iUDP could replace mKM to detect acute toxicity of substances with comparable and reliable result. And it is suitable for valuable or minor amount substances.
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Zhang, Y., Huang, Y., Liang, J., & Zhou, H. (2022). Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method. BMC Pharmacology and Toxicology, 23(1), 3. https://doi.org/10.1186/s40360-021-00541-7
Zhang, Yanyu, et al. "Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method." BMC Pharmacology and Toxicology, vol. 23, no. 1, 2022, pp. 3, https://doi.org/10.1186/s40360-021-00541-7.
Zhang, Yanyu, Yu‐Feng Huang, Jie Liang, and Hua Zhou. "Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method." BMC Pharmacology and Toxicology 23, no. 1 (2022): 3. https://doi.org/10.1186/s40360-021-00541-7.
Zhang Y., Huang Y., Liang J. [и др.] Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method // BMC Pharmacology and Toxicology. — 2022. — Vol. 23, № 1. — P. 3. — URL: https://doi.org/10.1186/s40360-021-00541-7
@article{zhang2022improved,
title = {{Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method}},
author = {Yanyu Zhang and Yu‐Feng Huang and Jie Liang and Hua Zhou},
journal = {BMC Pharmacology and Toxicology},
year = {2022},
volume = {23},
number = {1},
pages = {3},
doi = {10.1186/s40360-021-00541-7},
url = {https://doi.org/10.1186/s40360-021-00541-7}
}TY - JOUR AU - Zhang, Yanyu AU - Huang, Yu‐Feng AU - Liang, Jie AU - Zhou, Hua TI - Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method JO - BMC Pharmacology and Toxicology VL - 23 IS - 1 SP - 3 PY - 2022 DA - 2022/01/04 DO - 10.1186/s40360-021-00541-7 UR - https://doi.org/10.1186/s40360-021-00541-7 ER -
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