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Qiyu Zhang, Zhibin Yan, Yueming Meng, Xiangyu Hong, Gang Qin Shao, Junjie Ma, Xurui Cheng, Jun Liu, Jian Kang, Caiyun Fu
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
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Zhang, Q., Yan, Z., Meng, Y., Hong, X., Shao, G. Q., Ma, J., Cheng, X., Liu, J., Kang, J., & Fu, C. (2021). Antimicrobial peptides: mechanism of action, activity and clinical potential. Military Medical Research, 8(1), 48. https://doi.org/10.1186/s40779-021-00343-2
Zhang, Qiyu, et al. "Antimicrobial peptides: mechanism of action, activity and clinical potential." Military Medical Research, vol. 8, no. 1, 2021, pp. 48, https://doi.org/10.1186/s40779-021-00343-2.
Zhang, Qiyu, Zhibin Yan, Yueming Meng, Xiangyu Hong, Gang Qin Shao, Junjie Ma, Xurui Cheng, Jun Liu, Jian Kang, and Caiyun Fu. "Antimicrobial peptides: mechanism of action, activity and clinical potential." Military Medical Research 8, no. 1 (2021): 48. https://doi.org/10.1186/s40779-021-00343-2.
Zhang Q., Yan Z., Meng Y. [и др.] Antimicrobial peptides: mechanism of action, activity and clinical potential // Military Medical Research. — 2021. — Vol. 8, № 1. — P. 48. — URL: https://doi.org/10.1186/s40779-021-00343-2
@article{zhang2021antimicrobial,
title = {{Antimicrobial peptides: mechanism of action, activity and clinical potential}},
author = {Qiyu Zhang and Zhibin Yan and Yueming Meng and Xiangyu Hong and Gang Qin Shao and Junjie Ma and Xurui Cheng and Jun Liu and Jian Kang and Caiyun Fu},
journal = {Military Medical Research},
year = {2021},
volume = {8},
number = {1},
pages = {48},
doi = {10.1186/s40779-021-00343-2},
url = {https://doi.org/10.1186/s40779-021-00343-2}
}TY - JOUR AU - Zhang, Qiyu AU - Yan, Zhibin AU - Meng, Yueming AU - Hong, Xiangyu AU - Shao, Gang Qin AU - Ma, Junjie AU - Cheng, Xurui AU - Liu, Jun AU - Kang, Jian AU - Fu, Caiyun TI - Antimicrobial peptides: mechanism of action, activity and clinical potential JO - Military Medical Research VL - 8 IS - 1 SP - 48 PY - 2021 DA - 2021/09/08 DO - 10.1186/s40779-021-00343-2 UR - https://doi.org/10.1186/s40779-021-00343-2 ER -
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