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Aysha Karim Kiani, Derek Pheby, GARY T. M. HENEHAN, Richard E. Brown, Paul A. Sieving, Peter Sýkora, Robert Steven Marks, Benedetto Falsini, Natale Capodicasa, Stanislav Miertuš and 23 more
Animal experimentation is widely used around the world for the identification of the root causes of various diseases in humans and animals and for exploring treatment options. Among the several animal species, rats, mice and purpose-bred birds comprise almost 90% of the animals that are used for research purpose. However, growing awareness of the sentience of animals and their experience of pain and suffering has led to strong opposition to animal research among many scientists and the general public. In addition, the usefulness of extrapolating animal data to humans has been questioned. This has led to Ethical Committees' adoption of the 'four Rs' principles (Reduction, Refinement, Replacement and Responsibility) as a guide when making decisions regarding animal experimentation. Some of the essential considerations for humane animal experimentation are presented in this review along with the requirement for investigator training. Due to the ethical issues surrounding the use of animals in experimentation, their use is declining in those research areas where alternative in vitro or in silico methods are available. However, so far it has not been possible to dispense with experimental animals completely and further research is needed to provide a road map to robust alternatives before their use can be fully discontinued.
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Kiani, A. K., Pheby, D., HENEHAN, G. T. M., Brown, R. E., Sieving, P. A., Sýkora, P., Marks, R. S., Falsini, B., Capodicasa, N., Miertuš, S., Lorusso, L., Dondossola, D. E., Tartaglia, G. M., Ergören, M. Ç., Dündar, M., Michelini, S., Malacarne, D., Bonetti, G., Dautaj, A., … Bertelli, M. (2022). Ethical considerations regarding animal experimentation. Journal of preventive medicine and hygiene, 63(2 Suppl 3), E255–E266. https://doi.org/10.15167/2421-4248/jpmh2022.63.2s3.2768
Kiani, Aysha Karim, et al. "Ethical considerations regarding animal experimentation." Journal of preventive medicine and hygiene, vol. 63, no. 2 Suppl 3, 2022, pp. E255–E266, https://doi.org/10.15167/2421-4248/jpmh2022.63.2s3.2768.
Kiani, Aysha Karim, Derek Pheby, GARY T. M. HENEHAN, Richard E. Brown, Paul A. Sieving, Peter Sýkora, Robert Steven Marks, et al. "Ethical considerations regarding animal experimentation." Journal of preventive medicine and hygiene 63, no. 2 Suppl 3 (2022): E255–E266. https://doi.org/10.15167/2421-4248/jpmh2022.63.2s3.2768.
Kiani A. K., Pheby D., HENEHAN G. T. M. [и др.] Ethical considerations regarding animal experimentation // Journal of preventive medicine and hygiene. — 2022. — Vol. 63, № 2 Suppl 3. — P. E255–E266. — URL: https://doi.org/10.15167/2421-4248/jpmh2022.63.2s3.2768
@article{kiani2022ethical,
title = {{Ethical considerations regarding animal experimentation}},
author = {Aysha Karim Kiani and Derek Pheby and GARY T. M. HENEHAN and Richard E. Brown and Paul A. Sieving and Peter Sýkora and Robert Steven Marks and Benedetto Falsini and Natale Capodicasa and Stanislav Miertuš and Lorenzo Lorusso and Daniele Eliseo Dondossola and Gianluca Martino Tartaglia and Mahmut Çerkez Ergören and Munis Dündar and Sandro Michelini and Daniele Malacarne and G Bonetti and Astrit Dautaj and K Donato and Maria Chiara Medori and Tommaso Beccari and Michele Samaja and Stephen Connelly and Donald K. Martin and Assunta Morresi and Ariola Bacu and Karen Louise Herbst and Mykhaylo Kapustin and Liborio Stuppia and Ludovica Lumer and Giampietro Farronato and Matteo Bertelli},
journal = {Journal of preventive medicine and hygiene},
year = {2022},
volume = {63},
number = {2 Suppl 3},
pages = {E255--E266},
doi = {10.15167/2421-4248/jpmh2022.63.2s3.2768},
url = {https://doi.org/10.15167/2421-4248/jpmh2022.63.2s3.2768}
}TY - JOUR AU - Kiani, Aysha Karim AU - Pheby, Derek AU - HENEHAN, GARY T. M. AU - Brown, Richard E. AU - Sieving, Paul A. AU - Sýkora, Peter AU - Marks, Robert Steven AU - Falsini, Benedetto AU - Capodicasa, Natale AU - Miertuš, Stanislav AU - Lorusso, Lorenzo AU - Dondossola, Daniele Eliseo AU - Tartaglia, Gianluca Martino AU - Ergören, Mahmut Çerkez AU - Dündar, Munis AU - Michelini, Sandro AU - Malacarne, Daniele AU - Bonetti, G AU - Dautaj, Astrit AU - Donato, K AU - Medori, Maria Chiara AU - Beccari, Tommaso AU - Samaja, Michele AU - Connelly, Stephen AU - Martin, Donald K. AU - Morresi, Assunta AU - Bacu, Ariola AU - Herbst, Karen Louise AU - Kapustin, Mykhaylo AU - Stuppia, Liborio AU - Lumer, Ludovica AU - Farronato, Giampietro AU - Bertelli, Matteo TI - Ethical considerations regarding animal experimentation JO - Journal of preventive medicine and hygiene VL - 63 IS - 2 Suppl 3 SP - E255 EP - E266 PY - 2022 DA - 2022/10/16 DO - 10.15167/2421-4248/jpmh2022.63.2s3.2768 UR - https://doi.org/10.15167/2421-4248/jpmh2022.63.2s3.2768 ER -
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