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Mahmood Barani, Enrico Sangiovanni, Marco Angarano, Mohammad Amin Rajizadeh, Mehrnaz Mehrabani, Stefano Piazza, Hosahalli Veerabhadrappa Gangadharappa, Abbas Pardakhty, Mehrzad Mehrbani, Mario Dell’Agli, Mohammad Hadi Nematollahi
Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improve bio-efficacy in transporting dietary phytochemicals. Different methods have been proposed for generating effective carrier systems to enhance the bioavailability of phytochemicals. Among them, nano-vesicles have been introduced as promising candidates for the delivery of insoluble phytochemicals. Due to the easy preparation of the bilayer vesicles and their adaptability, they have been widely used and approved by the scientific literature. The first part of the review is focused on introducing phytosome technology as well as its applications, with emphasis on principles of formulations and characterization. The second part provides a wide overview of biological activities of commercial and non-commercial phytosomes, divided by systems and related pathologies. These results confirm the greater effectiveness of phytosomes, both in terms of biological activity or reduced dosage, highlighting curcumin and silymarin as the most formulated compounds. Finally, we describe the promising clinical and experimental findings regarding the applications of phytosomes. The conclusion of this study encourages the researchers to transfer their knowledge from laboratories to market, for a further development of these products.
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Barani, M., Sangiovanni, E., Angarano, M., Rajizadeh, M. A., Mehrabani, M., Piazza, S., Gangadharappa, H. V., Pardakhty, A., Mehrbani, M., Dell’Agli, M., & Nematollahi, M. H. (2021). Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature. International Journal of Nanomedicine, Volume 16, 6983–7022. https://doi.org/10.2147/ijn.s318416
Barani, Mahmood, et al. "Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature." International Journal of Nanomedicine, vol. Volume 16, 2021, pp. 6983–7022, https://doi.org/10.2147/ijn.s318416.
Barani, Mahmood, Enrico Sangiovanni, Marco Angarano, Mohammad Amin Rajizadeh, Mehrnaz Mehrabani, Stefano Piazza, Hosahalli Veerabhadrappa Gangadharappa, et al. "Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature." International Journal of Nanomedicine Volume 16 (2021): 6983–7022. https://doi.org/10.2147/ijn.s318416.
Barani M., Sangiovanni E., Angarano M. [и др.] Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature // International Journal of Nanomedicine. — 2021. — Vol. Volume 16. — P. 6983–7022. — URL: https://doi.org/10.2147/ijn.s318416
@article{barani2021phytosomes,
title = {{Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature}},
author = {Mahmood Barani and Enrico Sangiovanni and Marco Angarano and Mohammad Amin Rajizadeh and Mehrnaz Mehrabani and Stefano Piazza and Hosahalli Veerabhadrappa Gangadharappa and Abbas Pardakhty and Mehrzad Mehrbani and Mario Dell’Agli and Mohammad Hadi Nematollahi},
journal = {International Journal of Nanomedicine},
year = {2021},
volume = {Volume 16},
pages = {6983--7022},
doi = {10.2147/ijn.s318416},
url = {https://doi.org/10.2147/ijn.s318416}
}TY - JOUR AU - Barani, Mahmood AU - Sangiovanni, Enrico AU - Angarano, Marco AU - Rajizadeh, Mohammad Amin AU - Mehrabani, Mehrnaz AU - Piazza, Stefano AU - Gangadharappa, Hosahalli Veerabhadrappa AU - Pardakhty, Abbas AU - Mehrbani, Mehrzad AU - Dell’Agli, Mario AU - Nematollahi, Mohammad Hadi TI - Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature JO - International Journal of Nanomedicine VL - Volume 16 SP - 6983 EP - 7022 PY - 2021 DA - 2021/10/01 DO - 10.2147/ijn.s318416 UR - https://doi.org/10.2147/ijn.s318416 ER -
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