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Milan M. Obradovic, Emina M. Sudar-Milovanovic, Sanja Šoškić, Magbubah Essack, Swati Arya, Alan James Stewart, Takashi Gojobori, Esma R. Isenović
The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese ( ob ) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic effects, playing a crucial role in regulating body mass via a negative feedback mechanism between adipose tissue and the hypothalamus. Leptin resistance is characterized by reduced satiety, over-consumption of nutrients, and increased total body mass. Often this leads to obesity, which reduces the effectiveness of using exogenous leptin as a therapeutic agent. Thus, combining leptin therapies with leptin sensitizers may help overcome such resistance and, consequently, obesity. This review examines recent data obtained from human and animal studies related to leptin, its role in obesity, and its usefulness in obesity treatment.
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Obradovic, M. M., Sudar-Milovanovic, E. M., Šoškić, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenović, E. R. (2021). Leptin and Obesity: Role and Clinical Implication. Frontiers in Endocrinology, 12, 585887. https://doi.org/10.3389/fendo.2021.585887
Obradovic, Milan M., et al. "Leptin and Obesity: Role and Clinical Implication." Frontiers in Endocrinology, vol. 12, 2021, pp. 585887, https://doi.org/10.3389/fendo.2021.585887.
Obradovic, Milan M., Emina M. Sudar-Milovanovic, Sanja Šoškić, Magbubah Essack, Swati Arya, Alan James Stewart, Takashi Gojobori, and Esma R. Isenović. "Leptin and Obesity: Role and Clinical Implication." Frontiers in Endocrinology 12 (2021): 585887. https://doi.org/10.3389/fendo.2021.585887.
Obradovic M. M., Sudar-Milovanovic E. M., Šoškić S. [и др.] Leptin and Obesity: Role and Clinical Implication // Frontiers in Endocrinology. — 2021. — Vol. 12. — P. 585887. — URL: https://doi.org/10.3389/fendo.2021.585887
@article{obradovic2021leptin,
title = {{Leptin and Obesity: Role and Clinical Implication}},
author = {Milan M. Obradovic and Emina M. Sudar-Milovanovic and Sanja Šoškić and Magbubah Essack and Swati Arya and Alan James Stewart and Takashi Gojobori and Esma R. Isenović},
journal = {Frontiers in Endocrinology},
year = {2021},
volume = {12},
pages = {585887},
doi = {10.3389/fendo.2021.585887},
url = {https://doi.org/10.3389/fendo.2021.585887}
}TY - JOUR AU - Obradovic, Milan M. AU - Sudar-Milovanovic, Emina M. AU - Šoškić, Sanja AU - Essack, Magbubah AU - Arya, Swati AU - Stewart, Alan James AU - Gojobori, Takashi AU - Isenović, Esma R. TI - Leptin and Obesity: Role and Clinical Implication JO - Frontiers in Endocrinology VL - 12 SP - 585887 PY - 2021 DA - 2021/05/18 DO - 10.3389/fendo.2021.585887 UR - https://doi.org/10.3389/fendo.2021.585887 ER -
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