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Laura E. Carr, Misty Virmani, Fernanda Trindade da Rosa, Daniel Munblit, Katelin S. Matazel, Ahmed A. Elolimy, Laxmi Yeruva
Exclusive human milk feeding of the newborn is recommended during the first 6 months of life to promote optimal health outcomes during early life and beyond. Human milk contains a variety of bioactive factors such as hormones, cytokines, leukocytes, immunoglobulins, lactoferrin, lysozyme, stem cells, human milk oligosaccharides (HMOs), microbiota, and microRNAs. Recent findings highlighted the potential importance of adding HMOs into infant formula for their roles in enhancing host defense mechanisms in neonates. Therefore, understanding the roles of human milk bioactive factors on immune function is critical to build the scientific evidence base around breastfeeding recommendations, and to enhance positive health outcomes in formula fed infants through modifications to formulas. However, there are still knowledge gaps concerning the roles of different milk components, the interactions between the different components, and the mechanisms behind health outcomes are poorly understood. This review aims to show the current knowledge about HMOs, milk microbiota, immunoglobulins, lactoferrin, and milk microRNAs (miRNAs) and how these could have similar mechanisms of regulating gut and microbiota function. It will also highlight the knowledge gaps for future research.
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Carr, L. E., Virmani, M., Rosa, F. T. D., Munblit, D., Matazel, K. S., Elolimy, A. A., & Yeruva, L. (2021). Role of Human Milk Bioactives on Infants' Gut and Immune Health. Frontiers in Immunology, 12, 604080. https://doi.org/10.3389/fimmu.2021.604080
Carr, Laura E., et al. "Role of Human Milk Bioactives on Infants' Gut and Immune Health." Frontiers in Immunology, vol. 12, 2021, pp. 604080, https://doi.org/10.3389/fimmu.2021.604080.
Carr, Laura E., Misty Virmani, Fernanda Trindade da Rosa, Daniel Munblit, Katelin S. Matazel, Ahmed A. Elolimy, and Laxmi Yeruva. "Role of Human Milk Bioactives on Infants' Gut and Immune Health." Frontiers in Immunology 12 (2021): 604080. https://doi.org/10.3389/fimmu.2021.604080.
Carr L. E., Virmani M., Rosa F. T. D. [и др.] Role of Human Milk Bioactives on Infants' Gut and Immune Health // Frontiers in Immunology. — 2021. — Vol. 12. — P. 604080. — URL: https://doi.org/10.3389/fimmu.2021.604080
@article{carr2021role,
title = {{Role of Human Milk Bioactives on Infants' Gut and Immune Health}},
author = {Laura E. Carr and Misty Virmani and Fernanda Trindade da Rosa and Daniel Munblit and Katelin S. Matazel and Ahmed A. Elolimy and Laxmi Yeruva},
journal = {Frontiers in Immunology},
year = {2021},
volume = {12},
pages = {604080},
doi = {10.3389/fimmu.2021.604080},
url = {https://doi.org/10.3389/fimmu.2021.604080}
}TY - JOUR AU - Carr, Laura E. AU - Virmani, Misty AU - Rosa, Fernanda Trindade da AU - Munblit, Daniel AU - Matazel, Katelin S. AU - Elolimy, Ahmed A. AU - Yeruva, Laxmi TI - Role of Human Milk Bioactives on Infants' Gut and Immune Health JO - Frontiers in Immunology VL - 12 SP - 604080 PY - 2021 DA - 2021/02/12 DO - 10.3389/fimmu.2021.604080 UR - https://doi.org/10.3389/fimmu.2021.604080 ER -
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