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Xiaoyu Sun, Jike Gao, Xiang Ling Meng, Xiaoxuan Lu, Lei Zhang, Ran Chen
Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response in the host may cause the destruction of supporting periodontal tissue. Macrophages play a variety of roles in PD, including regulatory and phagocytosis. Moreover, under the induction of different factors, macrophages polarize and form different functional phenotypes. Among them, M1-type macrophages with proinflammatory functions and M2-type macrophages with anti-inflammatory functions are the most representative, and both of them can regulate the tendency of the immune system to exert proinflammatory or anti-inflammatory functions. M1 and M2 macrophages are involved in the destructive and reparative stages of PD. Due to the complex microenvironment of PD, the dynamic development of PD, and various local mediators, increasing attention has been given to the study of macrophage polarization in PD. This review summarizes the role of macrophage polarization in the development of PD and its research progress.
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Sun, X., Gao, J., Meng, X. L., Lu, X., Zhang, L., & Chen, R. (2021). Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling. Frontiers in Immunology, 12, 763334. https://doi.org/10.3389/fimmu.2021.763334
Sun, Xiaoyu, et al. "Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling." Frontiers in Immunology, vol. 12, 2021, pp. 763334, https://doi.org/10.3389/fimmu.2021.763334.
Sun, Xiaoyu, Jike Gao, Xiang Ling Meng, Xiaoxuan Lu, Lei Zhang, and Ran Chen. "Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling." Frontiers in Immunology 12 (2021): 763334. https://doi.org/10.3389/fimmu.2021.763334.
Sun X., Gao J., Meng X. L. [и др.] Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling // Frontiers in Immunology. — 2021. — Vol. 12. — P. 763334. — URL: https://doi.org/10.3389/fimmu.2021.763334
@article{sun2021polarized,
title = {{Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling}},
author = {Xiaoyu Sun and Jike Gao and Xiang Ling Meng and Xiaoxuan Lu and Lei Zhang and Ran Chen},
journal = {Frontiers in Immunology},
year = {2021},
volume = {12},
pages = {763334},
doi = {10.3389/fimmu.2021.763334},
url = {https://doi.org/10.3389/fimmu.2021.763334}
}TY - JOUR AU - Sun, Xiaoyu AU - Gao, Jike AU - Meng, Xiang Ling AU - Lu, Xiaoxuan AU - Zhang, Lei AU - Chen, Ran TI - Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling JO - Frontiers in Immunology VL - 12 SP - 763334 PY - 2021 DA - 2021/12/07 DO - 10.3389/fimmu.2021.763334 UR - https://doi.org/10.3389/fimmu.2021.763334 ER -
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