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Bo Yang, Xuefei Pang, Zhipeng Li, Zhuofan Chen, Yan Wang
Periodontitis is one of the most common dental diseases. Compared with healthy periodontal tissues, the immune microenvironment plays the key role in periodontitis by allowing the invasion of pathogens. It is possible that modulating the immune microenvironment can supplement traditional treatments and may even promote periodontal regeneration by using stem cells, bacteria, etc. New anti-inflammatory therapies can enhance the generation of a viable local immune microenvironment and promote cell homing and tissue formation, thereby achieving higher levels of immune regulation and tissue repair. We screened recent studies to summarize the advances of the immunomodulatory treatments for periodontitis in the aspects of drug therapy, microbial therapy, stem cell therapy, gene therapy and other therapies. In addition, we included the changes of immune cells and cytokines in the immune microenvironment of periodontitis in the section of drug therapy so as to make it clearer how the treatments took effects accordingly. In the future, more research needs to be done to improve immunotherapy methods and understand the risks and long-term efficacy of these methods in periodontitis.
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Yang, B., Pang, X., Li, Z., Chen, Z., & Wang, Y. (2021). Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives. Frontiers in Immunology, 12, 781378. https://doi.org/10.3389/fimmu.2021.781378
Yang, Bo, et al. "Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives." Frontiers in Immunology, vol. 12, 2021, pp. 781378, https://doi.org/10.3389/fimmu.2021.781378.
Yang, Bo, Xuefei Pang, Zhipeng Li, Zhuofan Chen, and Yan Wang. "Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives." Frontiers in Immunology 12 (2021): 781378. https://doi.org/10.3389/fimmu.2021.781378.
Yang B., Pang X., Li Z. [и др.] Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives // Frontiers in Immunology. — 2021. — Vol. 12. — P. 781378. — URL: https://doi.org/10.3389/fimmu.2021.781378
@article{yang2021immunomodulation,
title = {{Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives}},
author = {Bo Yang and Xuefei Pang and Zhipeng Li and Zhuofan Chen and Yan Wang},
journal = {Frontiers in Immunology},
year = {2021},
volume = {12},
pages = {781378},
doi = {10.3389/fimmu.2021.781378},
url = {https://doi.org/10.3389/fimmu.2021.781378}
}TY - JOUR AU - Yang, Bo AU - Pang, Xuefei AU - Li, Zhipeng AU - Chen, Zhuofan AU - Wang, Yan TI - Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives JO - Frontiers in Immunology VL - 12 SP - 781378 PY - 2021 DA - 2021/11/19 DO - 10.3389/fimmu.2021.781378 UR - https://doi.org/10.3389/fimmu.2021.781378 ER -
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