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Tianhao Duan, Yang Du, Changsheng Xing, Helen Y. Wang, Rong‐Fu Wang
Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of innate immune responses. Since their discovery, TLRs have revolutionized the field of immunology by filling the gap between the initial recognition of pathogens by innate immune cells and the activation of the adaptive immune response. TLRs critically link innate immunity to adaptive immunity by regulating the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR signaling can directly regulate the T cell activation, growth, differentiation, development, and function under diverse physiological conditions. This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss how TLR signaling is critically important in the host's defense against infectious diseases, autoimmune diseases, and cancer.
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Duan, T., Du, Y., Xing, C., Wang, H. Y., & Wang, R. (2022). Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity. Frontiers in Immunology, 13, 812774. https://doi.org/10.3389/fimmu.2022.812774
Duan, Tianhao, et al. "Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity." Frontiers in Immunology, vol. 13, 2022, pp. 812774, https://doi.org/10.3389/fimmu.2022.812774.
Duan, Tianhao, Yang Du, Changsheng Xing, Helen Y. Wang, and Rong‐Fu Wang. "Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity." Frontiers in Immunology 13 (2022): 812774. https://doi.org/10.3389/fimmu.2022.812774.
Duan T., Du Y., Xing C. [и др.] Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity // Frontiers in Immunology. — 2022. — Vol. 13. — P. 812774. — URL: https://doi.org/10.3389/fimmu.2022.812774
@article{duan2022tolllike,
title = {{Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity}},
author = {Tianhao Duan and Yang Du and Changsheng Xing and Helen Y. Wang and Rong‐Fu Wang},
journal = {Frontiers in Immunology},
year = {2022},
volume = {13},
pages = {812774},
doi = {10.3389/fimmu.2022.812774},
url = {https://doi.org/10.3389/fimmu.2022.812774}
}TY - JOUR AU - Duan, Tianhao AU - Du, Yang AU - Xing, Changsheng AU - Wang, Helen Y. AU - Wang, Rong‐Fu TI - Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity JO - Frontiers in Immunology VL - 13 SP - 812774 PY - 2022 DA - 2022/03/03 DO - 10.3389/fimmu.2022.812774 UR - https://doi.org/10.3389/fimmu.2022.812774 ER -
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