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Jing Gao, Yuanzheng Liang, Liang Wang
Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) are composed of heterogeneous subpopulations, which include the M1 anti-tumor and M2 pro-tumor phenotypes. TAMs predominantly play a M2-like tumor-promoting role in the TME and regulate various malignant effects, such as angiogenesis, immune suppression, and tumor metastasis; hence, TAMs have emerged as a hot topic of research in cancer therapy. This review focuses on three main aspects of TAMs. First, we summarize macrophage polarization along with the effects on the TME. Second, recent advances and challenges in cancer treatment and the role of M2-like TAMs in immune checkpoint blockade and CAR-T cell therapy are emphasized. Finally, factors, such as signaling pathways, associated with TAM polarization and potential strategies for targeting TAM repolarization to the M1 pro-inflammatory phenotype for cancer therapy are discussed.
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Gao, J., Liang, Y., & Wang, L. (2022). Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy. Frontiers in Immunology, 13, 888713. https://doi.org/10.3389/fimmu.2022.888713
Gao, Jing, et al. "Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy." Frontiers in Immunology, vol. 13, 2022, pp. 888713, https://doi.org/10.3389/fimmu.2022.888713.
Gao, Jing, Yuanzheng Liang, and Liang Wang. "Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy." Frontiers in Immunology 13 (2022): 888713. https://doi.org/10.3389/fimmu.2022.888713.
Gao J., Liang Y., Wang L. Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy // Frontiers in Immunology. — 2022. — Vol. 13. — P. 888713. — URL: https://doi.org/10.3389/fimmu.2022.888713
@article{gao2022shaping,
title = {{Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy}},
author = {Jing Gao and Yuanzheng Liang and Liang Wang},
journal = {Frontiers in Immunology},
year = {2022},
volume = {13},
pages = {888713},
doi = {10.3389/fimmu.2022.888713},
url = {https://doi.org/10.3389/fimmu.2022.888713}
}TY - JOUR AU - Gao, Jing AU - Liang, Yuanzheng AU - Wang, Liang TI - Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy JO - Frontiers in Immunology VL - 13 SP - 888713 PY - 2022 DA - 2022/06/30 DO - 10.3389/fimmu.2022.888713 UR - https://doi.org/10.3389/fimmu.2022.888713 ER -
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