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Shenrui Guo, Hui Wang, Yafu Yin
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Microglia can be categorized into two opposite types: classical (M1) or alternative (M2), though there's a continuum of different intermediate phenotypes between M1 and M2, and microglia can transit from one phenotype to another. M1 microglia release inflammatory mediators and induce inflammation and neurotoxicity, while M2 microglia release anti-inflammatory mediators and induce anti-inflammatory and neuroprotectivity. Microglia-mediated neuroinflammation is considered as a double-edged sword, performing both harmful and helpful effects in neurodegenerative diseases. Previous studies showed that balancing microglia M1/M2 polarization had a promising therapeutic prospect in neurodegenerative diseases. We suggest that shifting microglia from M1 to M2 may be significant and we focus on the modulation of microglia polarization from M1 to M2, especially by important signal pathways, in neurodegenerative diseases.
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Guo, S., Wang, H., & Yin, Y. (2022). Microglia Polarization From M1 to M2 in Neurodegenerative Diseases. Frontiers in Aging Neuroscience, 14, 815347. https://doi.org/10.3389/fnagi.2022.815347
Guo, Shenrui, et al. "Microglia Polarization From M1 to M2 in Neurodegenerative Diseases." Frontiers in Aging Neuroscience, vol. 14, 2022, pp. 815347, https://doi.org/10.3389/fnagi.2022.815347.
Guo, Shenrui, Hui Wang, and Yafu Yin. "Microglia Polarization From M1 to M2 in Neurodegenerative Diseases." Frontiers in Aging Neuroscience 14 (2022): 815347. https://doi.org/10.3389/fnagi.2022.815347.
Guo S., Wang H., Yin Y. Microglia Polarization From M1 to M2 in Neurodegenerative Diseases // Frontiers in Aging Neuroscience. — 2022. — Vol. 14. — P. 815347. — URL: https://doi.org/10.3389/fnagi.2022.815347
@article{guo2022microglia,
title = {{Microglia Polarization From M1 to M2 in Neurodegenerative Diseases}},
author = {Shenrui Guo and Hui Wang and Yafu Yin},
journal = {Frontiers in Aging Neuroscience},
year = {2022},
volume = {14},
pages = {815347},
doi = {10.3389/fnagi.2022.815347},
url = {https://doi.org/10.3389/fnagi.2022.815347}
}TY - JOUR AU - Guo, Shenrui AU - Wang, Hui AU - Yin, Yafu TI - Microglia Polarization From M1 to M2 in Neurodegenerative Diseases JO - Frontiers in Aging Neuroscience VL - 14 SP - 815347 PY - 2022 DA - 2022/02/16 DO - 10.3389/fnagi.2022.815347 UR - https://doi.org/10.3389/fnagi.2022.815347 ER -
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