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Fabrizio Grieco, Briana J. Bernstein, Barbara Biemans, Lior Bikovski, C. Joseph Burnett, Jesse D. Cushman, Elsbeth A. van Dam, Sydney A. Fry, Bar Richmond-Hacham, Judith Regina Homberg and 19 more
The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue in the field of behavioral neuroscience, where, in spite of efforts to standardize testing and assay protocols, several known and unknown sources of confounding environmental factors add to variance. Human interference is a major contributor to variability both within and across laboratories, as well as novelty-induced anxiety. Attempts to reduce human interference and to measure more "natural" behaviors in subjects has led to the development of automated home-cage monitoring systems. These systems enable prolonged and longitudinal recordings, and provide large continuous measures of spontaneous behavior that can be analyzed across multiple time scales. In this review, a diverse team of neuroscientists and product developers share their experiences using such an automated monitoring system that combines Noldus PhenoTyper® home-cages and the video-based tracking software, EthoVision® XT, to extract digital biomarkers of motor, emotional, social and cognitive behavior. After presenting our working definition of a “home-cage”, we compare home-cage testing with more conventional out-of-cage tests (e.g., the open field) and outline the various advantages of the former, including opportunities for within-subject analyses and assessments of circadian and ultradian activity. Next, we address technical issues pertaining to the acquisition of behavioral data, such as the fine-tuning of the tracking software and the potential for integration with biotelemetry and optogenetics. Finally, we provide guidance on which behavioral measures to emphasize, how to filter, segment, and analyze behavior, and how to use analysis scripts. We summarize how the PhenoTyper has applications to study neuropharmacology as well as animal models of neurodegenerative and neuropsychiatric illness. Looking forward, we examine current challenges and the impact of new developments. Examples include the automated recognition of specific behaviors, unambiguous tracking of individuals in a social context, the development of more animal-centered measures of behavior and ways of dealing with large datasets. Together, we advocate that by embracing standardized home-cage monitoring platforms like the PhenoTyper, we are poised to directly assess issues pertaining to reproducibility, and more importantly, measure features of rodent behavior under more ethologically relevant scenarios.
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Grieco, F., Bernstein, B. J., Biemans, B., Bikovski, L., Burnett, C. J., Cushman, J. D., Dam, E. A. V., Fry, S. A., Richmond-Hacham, B., Homberg, J. R., Kas, M. J., Kessels, H. W. H. G., Koopmans, B., Krashes, M. J., Krishnan, V., Logan, S., Loos, M., McCann, K. E., Parduzi, Q., … Noldus, L. P. J. J. (2021). Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives. Frontiers in Behavioral Neuroscience, 15, 735387. https://doi.org/10.3389/fnbeh.2021.735387
Grieco, Fabrizio, et al. "Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives." Frontiers in Behavioral Neuroscience, vol. 15, 2021, pp. 735387, https://doi.org/10.3389/fnbeh.2021.735387.
Grieco, Fabrizio, Briana J. Bernstein, Barbara Biemans, Lior Bikovski, C. Joseph Burnett, Jesse D. Cushman, Elsbeth A. van Dam, et al. "Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives." Frontiers in Behavioral Neuroscience 15 (2021): 735387. https://doi.org/10.3389/fnbeh.2021.735387.
Grieco F., Bernstein B. J., Biemans B. [и др.] Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives // Frontiers in Behavioral Neuroscience. — 2021. — Vol. 15. — P. 735387. — URL: https://doi.org/10.3389/fnbeh.2021.735387
@article{grieco2021measuring,
title = {{Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives}},
author = {Fabrizio Grieco and Briana J. Bernstein and Barbara Biemans and Lior Bikovski and C. Joseph Burnett and Jesse D. Cushman and Elsbeth A. van Dam and Sydney A. Fry and Bar Richmond-Hacham and Judith Regina Homberg and Martien J. Kas and Helmut W. H. G. Kessels and Bastijn Koopmans and Michael J. Krashes and Vaishnav Krishnan and Sreemathi Logan and Maarten Loos and Katharine E McCann and Qendresa Parduzi and Chaim G. Pick and Thomas D. Prévot and Gernot Riedel and Lianne Robinson and Mina Sadighi and August Benjamin Smit and William Edmund Sonntag and Reinko F. Roelofs and Ruud A.J. Tegelenbosch and Lucas P. J. J. Noldus},
journal = {Frontiers in Behavioral Neuroscience},
year = {2021},
volume = {15},
pages = {735387},
doi = {10.3389/fnbeh.2021.735387},
url = {https://doi.org/10.3389/fnbeh.2021.735387}
}TY - JOUR AU - Grieco, Fabrizio AU - Bernstein, Briana J. AU - Biemans, Barbara AU - Bikovski, Lior AU - Burnett, C. Joseph AU - Cushman, Jesse D. AU - Dam, Elsbeth A. van AU - Fry, Sydney A. AU - Richmond-Hacham, Bar AU - Homberg, Judith Regina AU - Kas, Martien J. AU - Kessels, Helmut W. H. G. AU - Koopmans, Bastijn AU - Krashes, Michael J. AU - Krishnan, Vaishnav AU - Logan, Sreemathi AU - Loos, Maarten AU - McCann, Katharine E AU - Parduzi, Qendresa AU - Pick, Chaim G. AU - Prévot, Thomas D. AU - Riedel, Gernot AU - Robinson, Lianne AU - Sadighi, Mina AU - Smit, August Benjamin AU - Sonntag, William Edmund AU - Roelofs, Reinko F. AU - Tegelenbosch, Ruud A.J. AU - Noldus, Lucas P. J. J. TI - Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives JO - Frontiers in Behavioral Neuroscience VL - 15 SP - 735387 PY - 2021 DA - 2021/09/24 DO - 10.3389/fnbeh.2021.735387 UR - https://doi.org/10.3389/fnbeh.2021.735387 ER -
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