One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Luca Muzio, Alice Viotti, Gianvito Martino
Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris. Microglia emerge from early erythromyeloid progenitors of the yolk sac and enter the developing brain before the establishment of a fully mature blood-brain barrier. In physiological conditions, during brain development, microglia contribute to CNS homeostasis by supporting cell proliferation of neural precursors. In post-natal life, such cells contribute to preserving the integrity of neuronal circuits by sculpting synapses. After a CNS injury, microglia change their morphology and down-regulate those genes supporting homeostatic functions. However, it is still unclear whether such changes are accompanied by molecular and functional modifications that might contribute to the pathological process. While comprehensive transcriptome analyses at the single-cell level have identified specific gene perturbations occurring in the "pathological" microglia, still the precise protective/detrimental role of microglia in neurological disorders is far from being fully elucidated. In this review, the results so far obtained regarding the role of microglia in neurodegenerative disorders will be discussed. There is solid and sound evidence suggesting that regulating microglia functions during disease pathology might represent a strategy to develop future therapies aimed at counteracting brain degeneration in multiple sclerosis, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Muzio, L., Viotti, A., & Martino, G. (2021). Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy. Frontiers in Neuroscience, 15, 742065. https://doi.org/10.3389/fnins.2021.742065
Muzio, Luca, et al. "Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy." Frontiers in Neuroscience, vol. 15, 2021, pp. 742065, https://doi.org/10.3389/fnins.2021.742065.
Muzio, Luca, Alice Viotti, and Gianvito Martino. "Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy." Frontiers in Neuroscience 15 (2021): 742065. https://doi.org/10.3389/fnins.2021.742065.
Muzio L., Viotti A., Martino G. Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy // Frontiers in Neuroscience. — 2021. — Vol. 15. — P. 742065. — URL: https://doi.org/10.3389/fnins.2021.742065
@article{muzio2021microglia,
title = {{Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy}},
author = {Luca Muzio and Alice Viotti and Gianvito Martino},
journal = {Frontiers in Neuroscience},
year = {2021},
volume = {15},
pages = {742065},
doi = {10.3389/fnins.2021.742065},
url = {https://doi.org/10.3389/fnins.2021.742065}
}TY - JOUR AU - Muzio, Luca AU - Viotti, Alice AU - Martino, Gianvito TI - Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy JO - Frontiers in Neuroscience VL - 15 SP - 742065 PY - 2021 DA - 2021/09/24 DO - 10.3389/fnins.2021.742065 UR - https://doi.org/10.3389/fnins.2021.742065 ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.