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Kamari Weaver, Rachid Skouta
The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a reducing agent. GPX4 has become a hotspot therapeutic target in biomedical research following its characterization as a chief regulator of ferroptosis, and its subsequent recognition as a specific pharmacological target for the treatment of an extensive variety of human diseases including cancers and neurodegenerative disorders. Several recent studies have provided insights into how GPX4 is distinguished from the rest of the glutathione peroxidase family, the unique biochemical properties of GPX4, how GPX4 is related to lipid peroxidation and ferroptosis, and how the enzyme may be modulated as a potential therapeutic target. This current report aims to review the literature underlying all these insights and present an up-to-date perspective on the current understanding of GPX4 as a potential therapeutic target.
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Weaver, K., & Skouta, R. (2022). The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities. Biomedicines, 10(4), 891. https://doi.org/10.3390/biomedicines10040891
Weaver, Kamari, and Rachid Skouta. "The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities." Biomedicines, vol. 10, no. 4, 2022, pp. 891, https://doi.org/10.3390/biomedicines10040891.
Weaver, Kamari, and Rachid Skouta. "The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities." Biomedicines 10, no. 4 (2022): 891. https://doi.org/10.3390/biomedicines10040891.
Weaver K., Skouta R. The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities // Biomedicines. — 2022. — Vol. 10, № 4. — P. 891. — URL: https://doi.org/10.3390/biomedicines10040891
@article{weaver2022selenoprotein,
title = {{The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities}},
author = {Kamari Weaver and Rachid Skouta},
journal = {Biomedicines},
year = {2022},
volume = {10},
number = {4},
pages = {891},
doi = {10.3390/biomedicines10040891},
url = {https://doi.org/10.3390/biomedicines10040891}
}TY - JOUR AU - Weaver, Kamari AU - Skouta, Rachid TI - The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities JO - Biomedicines VL - 10 IS - 4 SP - 891 PY - 2022 DA - 2022/04/13 DO - 10.3390/biomedicines10040891 UR - https://doi.org/10.3390/biomedicines10040891 ER -
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