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Rachel Michelle Saré, Abigail H. S. Lemons, Carolyn Beebe Smith
Rodent models of brain disorders including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases are essential for increasing our understanding of underlying pathology and for preclinical testing of potential treatments. Some of the most important outcome measures in such studies are behavioral. Unfortunately, reports from different labs are often conflicting, and preclinical studies in rodent models are not often corroborated in human trials. There are many well-established tests for assessing various behavioral readouts, but subtle aspects can influence measurements. Features such as housing conditions, conditions of testing, and the sex and strain of the animals can all have effects on tests of behavior. In the conduct of behavior testing, it is important to keep these features in mind to ensure the reliability and reproducibility of results. In this review, we highlight factors that we and others have encountered that can influence behavioral measures. Our goal is to increase awareness of factors that can affect behavior in rodents and to emphasize the need for detailed reporting of methods.
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Saré, R. M., Lemons, A. H. S., & Smith, C. B. (2021). Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility. Brain Sciences, 11(4), 522. https://doi.org/10.3390/brainsci11040522
Saré, Rachel Michelle, et al. "Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility." Brain Sciences, vol. 11, no. 4, 2021, pp. 522, https://doi.org/10.3390/brainsci11040522.
Saré, Rachel Michelle, Abigail H. S. Lemons, and Carolyn Beebe Smith. "Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility." Brain Sciences 11, no. 4 (2021): 522. https://doi.org/10.3390/brainsci11040522.
Saré R. M., Lemons A. H. S., Smith C. B. Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility // Brain Sciences. — 2021. — Vol. 11, № 4. — P. 522. — URL: https://doi.org/10.3390/brainsci11040522
@article{sare2021behavior,
title = {{Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility}},
author = {Rachel Michelle Saré and Abigail H. S. Lemons and Carolyn Beebe Smith},
journal = {Brain Sciences},
year = {2021},
volume = {11},
number = {4},
pages = {522},
doi = {10.3390/brainsci11040522},
url = {https://doi.org/10.3390/brainsci11040522}
}TY - JOUR AU - Saré, Rachel Michelle AU - Lemons, Abigail H. S. AU - Smith, Carolyn Beebe TI - Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility JO - Brain Sciences VL - 11 IS - 4 SP - 522 PY - 2021 DA - 2021/04/20 DO - 10.3390/brainsci11040522 UR - https://doi.org/10.3390/brainsci11040522 ER -
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