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William Roth, Kimia Zadeh, Rushi Vekariya, Yong Ge, Mansour Mohamadzadeh
Tryptophan is an essential amino acid critical for protein synthesis in humans that has emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the neurotransmitter serotonin, which is vital for the processing of emotional regulation, hunger, sleep, and pain, as well as colonic motility and secretory activity in the gut. Tryptophan catabolites from the kynurenine degradation pathway also modulate neural activity and are active in the systemic inflammatory cascade. Additionally, tryptophan and its metabolites support the development of the central and enteric nervous systems. Accordingly, dysregulation of tryptophan metabolites plays a central role in the pathogenesis of many neurologic and psychiatric disorders. Gut microbes influence tryptophan metabolism directly and indirectly, with corresponding changes in behavior and cognition. The gut microbiome has thus garnered much attention as a therapeutic target for both neurologic and psychiatric disorders where tryptophan and its metabolites play a prominent role. In this review, we will touch upon some of these features and their involvement in health and disease.
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Roth, W., Zadeh, K., Vekariya, R., Ge, Y., & Mohamadzadeh, M. (2021). Tryptophan Metabolism and Gut-Brain Homeostasis. International Journal of Molecular Sciences, 22(6), 2973. https://doi.org/10.3390/ijms22062973
Roth, William, et al. "Tryptophan Metabolism and Gut-Brain Homeostasis." International Journal of Molecular Sciences, vol. 22, no. 6, 2021, pp. 2973, https://doi.org/10.3390/ijms22062973.
Roth, William, Kimia Zadeh, Rushi Vekariya, Yong Ge, and Mansour Mohamadzadeh. "Tryptophan Metabolism and Gut-Brain Homeostasis." International Journal of Molecular Sciences 22, no. 6 (2021): 2973. https://doi.org/10.3390/ijms22062973.
Roth W., Zadeh K., Vekariya R. [и др.] Tryptophan Metabolism and Gut-Brain Homeostasis // International Journal of Molecular Sciences. — 2021. — Vol. 22, № 6. — P. 2973. — URL: https://doi.org/10.3390/ijms22062973
@article{roth2021tryptophan,
title = {{Tryptophan Metabolism and Gut-Brain Homeostasis}},
author = {William Roth and Kimia Zadeh and Rushi Vekariya and Yong Ge and Mansour Mohamadzadeh},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
number = {6},
pages = {2973},
doi = {10.3390/ijms22062973},
url = {https://doi.org/10.3390/ijms22062973}
}TY - JOUR AU - Roth, William AU - Zadeh, Kimia AU - Vekariya, Rushi AU - Ge, Yong AU - Mohamadzadeh, Mansour TI - Tryptophan Metabolism and Gut-Brain Homeostasis JO - International Journal of Molecular Sciences VL - 22 IS - 6 SP - 2973 PY - 2021 DA - 2021/03/15 DO - 10.3390/ijms22062973 UR - https://doi.org/10.3390/ijms22062973 ER -
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