- Published
- 2021-06-28
- Venue
- International Journal of Molecular Sciences, vol. 22, no. 13, pp. 6965
- Cited by
- 256
- Open access
- Yes, gold
- DOI
- 10.3390/ijms22136965
- PubMed
- 34203461
Abstract
The dietary recommendation encourages reducing saturated fatty acids (SFA) in diet and replacing them with polyunsaturated fatty acids (PUFAs) n-3 (omega-3) and n-6 (omega-6) to decrease the risk of metabolic disturbances. Consequently, excessive n-6 PUFAs content and high n-6/n-3 ratio are found in Western-type diet. The importance of a dietary n-6/n-3 ratio to prevent chronic diseases is linked with anti-inflammatory functions of linolenic acid (ALA, 18:3n-3) and longer-chain n-3 PUFAs. Thus, this review provides an overview of the role of oxylipins derived from n-3 PUFAs and oxylipins formed from n-6 PUFAs on inflammation. Evidence of PUFAs' role in carcinogenesis was also discussed. In vitro studies, animal cancer models and epidemiological studies demonstrate that these two PUFA groups have different effects on the cell growth, proliferation and progression of neoplastic lesions.
Cite this paper
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- APA 7
Liput, K. P., Lepczyński, A., Ogłuszka, M., Nawrocka, A., Poławska, E., Grzesiak, A., Ślaska, B., Pareek, C. S., Czarnik, U., & Pierzchała, M. (2021). Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis. International Journal of Molecular Sciences, 22(13), 6965. https://doi.org/10.3390/ijms22136965
- MLA 9
Liput, Kamila P., et al. "Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis." International Journal of Molecular Sciences, vol. 22, no. 13, 2021, pp. 6965, https://doi.org/10.3390/ijms22136965.
- Chicago
Liput, Kamila P., Adam Lepczyński, Magdalena Ogłuszka, Agata Nawrocka, Ewa Poławska, Agata Grzesiak, Brygida Ślaska, Chandra S. Pareek, Urszula Czarnik, and Mariusz Pierzchała. "Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis." International Journal of Molecular Sciences 22, no. 13 (2021): 6965. https://doi.org/10.3390/ijms22136965.
- GOST
Liput K. P., Lepczyński A., Ogłuszka M. [и др.] Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis // International Journal of Molecular Sciences. — 2021. — Vol. 22, № 13. — P. 6965. — URL: https://doi.org/10.3390/ijms22136965
- BibTeX
@article{liput2021effects, title = {{Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis}}, author = {Kamila P. Liput and Adam Lepczyński and Magdalena Ogłuszka and Agata Nawrocka and Ewa Poławska and Agata Grzesiak and Brygida Ślaska and Chandra S. Pareek and Urszula Czarnik and Mariusz Pierzchała}, journal = {International Journal of Molecular Sciences}, year = {2021}, volume = {22}, number = {13}, pages = {6965}, doi = {10.3390/ijms22136965}, url = {https://doi.org/10.3390/ijms22136965} }- RIS
TY - JOUR AU - Liput, Kamila P. AU - Lepczyński, Adam AU - Ogłuszka, Magdalena AU - Nawrocka, Agata AU - Poławska, Ewa AU - Grzesiak, Agata AU - Ślaska, Brygida AU - Pareek, Chandra S. AU - Czarnik, Urszula AU - Pierzchała, Mariusz TI - Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis JO - International Journal of Molecular Sciences VL - 22 IS - 13 SP - 6965 PY - 2021 DA - 2021/06/28 DO - 10.3390/ijms22136965 UR - https://doi.org/10.3390/ijms22136965 ER -
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