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Arun Butreddy, Rajendra Prasad Gaddam, Nagavendra Kommineni, Narendar Reddy Dudhipala, Chandrashekhar Voshavar
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide (PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled drug delivery to reduce dosing frequency and to improve the therapeutic effects. Biopharmaceuticals such as proteins and peptides are encapsulated in the microspheres to increase their bioavailability and provide a long release period (days or months) with constant drug plasma concentration. The biodegradable and biocompatible properties of PLGA/PLA polymers, including but not limited to molecular weight, end group, lactide to glycolide ratio, and minor manufacturing changes, could greatly affect the quality attributes of microsphere formulations such as release profile, size, encapsulation efficiency, and bioactivity of biopharmaceuticals. Besides, the encapsulated proteins/peptides are susceptible to harsh processing conditions associated with microsphere fabrication methods, including exposure to organic solvent, shear stress, and temperature fluctuations. The protein/peptide containing LAI microspheres in clinical use is typically prepared by double emulsion, coacervation, and spray drying techniques. The purpose of this review is to provide an overview of the formulation attributes and conventional manufacturing techniques of LAI microspheres that are currently in clinical use for protein/peptides. Furthermore, the physicochemical characteristics of the microsphere formulations are deliberated.
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Butreddy, A., Gaddam, R. P., Kommineni, N., Dudhipala, N. R., & Voshavar, C. (2021). PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery. International Journal of Molecular Sciences, 22(16), 8884. https://doi.org/10.3390/ijms22168884
Butreddy, Arun, et al. "PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery." International Journal of Molecular Sciences, vol. 22, no. 16, 2021, pp. 8884, https://doi.org/10.3390/ijms22168884.
Butreddy, Arun, Rajendra Prasad Gaddam, Nagavendra Kommineni, Narendar Reddy Dudhipala, and Chandrashekhar Voshavar. "PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery." International Journal of Molecular Sciences 22, no. 16 (2021): 8884. https://doi.org/10.3390/ijms22168884.
Butreddy A., Gaddam R. P., Kommineni N. [и др.] PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery // International Journal of Molecular Sciences. — 2021. — Vol. 22, № 16. — P. 8884. — URL: https://doi.org/10.3390/ijms22168884
@article{butreddy2021plgaplabased,
title = {{PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery}},
author = {Arun Butreddy and Rajendra Prasad Gaddam and Nagavendra Kommineni and Narendar Reddy Dudhipala and Chandrashekhar Voshavar},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
number = {16},
pages = {8884},
doi = {10.3390/ijms22168884},
url = {https://doi.org/10.3390/ijms22168884}
}TY - JOUR AU - Butreddy, Arun AU - Gaddam, Rajendra Prasad AU - Kommineni, Nagavendra AU - Dudhipala, Narendar Reddy AU - Voshavar, Chandrashekhar TI - PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery JO - International Journal of Molecular Sciences VL - 22 IS - 16 SP - 8884 PY - 2021 DA - 2021/08/18 DO - 10.3390/ijms22168884 UR - https://doi.org/10.3390/ijms22168884 ER -
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