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Anamaria Jurcău, Aurel Simion
Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which neuroinflammation is significantly involved. Research has shown that in the acute phase, neuroinflammatory cascades lead to apoptosis, disruption of the blood-brain barrier, cerebral edema, and hemorrhagic transformation, while in later stages, these pathways support tissue repair and functional recovery. The present review discusses the various cell types and the mechanisms through which neuroinflammation contributes to parenchymal injury and tissue repair, as well as therapeutic attempts made in vitro, in animal experiments, and in clinical trials which target neuroinflammation, highlighting future therapeutic perspectives.
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Jurcău, A., & Simion, A. (2021). Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies. International Journal of Molecular Sciences, 23(1), 14. https://doi.org/10.3390/ijms23010014
Jurcău, Anamaria, and Aurel Simion. "Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies." International Journal of Molecular Sciences, vol. 23, no. 1, 2021, pp. 14, https://doi.org/10.3390/ijms23010014.
Jurcău, Anamaria, and Aurel Simion. "Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies." International Journal of Molecular Sciences 23, no. 1 (2021): 14. https://doi.org/10.3390/ijms23010014.
Jurcău A., Simion A. Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies // International Journal of Molecular Sciences. — 2021. — Vol. 23, № 1. — P. 14. — URL: https://doi.org/10.3390/ijms23010014
@article{jurcau2021neuroinflammation,
title = {{Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies}},
author = {Anamaria Jurcău and Aurel Simion},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {23},
number = {1},
pages = {14},
doi = {10.3390/ijms23010014},
url = {https://doi.org/10.3390/ijms23010014}
}TY - JOUR AU - Jurcău, Anamaria AU - Simion, Aurel TI - Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies JO - International Journal of Molecular Sciences VL - 23 IS - 1 SP - 14 PY - 2021 DA - 2021/12/21 DO - 10.3390/ijms23010014 UR - https://doi.org/10.3390/ijms23010014 ER -
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