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Richard Nii Lante Lamptey, Bivek Chaulagain, Riddhi Trivedi, Avinash Gothwal, Buddhadev Layek, Jagdish Singh
Neurodegenerative disorders are primarily characterized by neuron loss. The most common neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there are several medicines currently approved for managing neurodegenerative disorders, a large majority of them only help with associated symptoms. This lack of pathogenesis-targeting therapies is primarily due to the restrictive effects of the blood-brain barrier (BBB), which keeps close to 99% of all "foreign substances" out of the brain. Since their discovery, nanoparticles have been successfully used for targeted delivery into many organs, including the brain. This review briefly describes the pathophysiology of Alzheimer's, Parkinson's disease, and amyotrophic lateral sclerosis, and their current management approaches. We then highlight the major challenges of brain-drug delivery, followed by the role of nanotherapeutics for the diagnosis and treatment of various neurological disorders.
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Lamptey, R. N. L., Chaulagain, B., Trivedi, R., Gothwal, A., Layek, B., & Singh, J. (2022). A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics. International Journal of Molecular Sciences, 23(3), 1851. https://doi.org/10.3390/ijms23031851
Lamptey, Richard Nii Lante, et al. "A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics." International Journal of Molecular Sciences, vol. 23, no. 3, 2022, pp. 1851, https://doi.org/10.3390/ijms23031851.
Lamptey, Richard Nii Lante, Bivek Chaulagain, Riddhi Trivedi, Avinash Gothwal, Buddhadev Layek, and Jagdish Singh. "A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics." International Journal of Molecular Sciences 23, no. 3 (2022): 1851. https://doi.org/10.3390/ijms23031851.
Lamptey R. N. L., Chaulagain B., Trivedi R. [и др.] A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics // International Journal of Molecular Sciences. — 2022. — Vol. 23, № 3. — P. 1851. — URL: https://doi.org/10.3390/ijms23031851
@article{lamptey2022review,
title = {{A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics}},
author = {Richard Nii Lante Lamptey and Bivek Chaulagain and Riddhi Trivedi and Avinash Gothwal and Buddhadev Layek and Jagdish Singh},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
number = {3},
pages = {1851},
doi = {10.3390/ijms23031851},
url = {https://doi.org/10.3390/ijms23031851}
}TY - JOUR AU - Lamptey, Richard Nii Lante AU - Chaulagain, Bivek AU - Trivedi, Riddhi AU - Gothwal, Avinash AU - Layek, Buddhadev AU - Singh, Jagdish TI - A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics JO - International Journal of Molecular Sciences VL - 23 IS - 3 SP - 1851 PY - 2022 DA - 2022/02/06 DO - 10.3390/ijms23031851 UR - https://doi.org/10.3390/ijms23031851 ER -
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