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Mattia Di Stefano, Alessandro Polizzi, Simona Santonocito, Alessandra Romano, Teresa Lombardi, Gaetano Isola
The skin, oral cavity, digestive and reproductive tracts of the human body harbor symbiotic and commensal microorganisms living harmoniously with the host. The oral cavity houses one of the most heterogeneous microbial communities found in the human organism, ranking second in terms of species diversity and complexity only to the gastrointestinal microbiota and including bacteria, archaea, fungi, and viruses. The accumulation of microbial plaque in the oral cavity may lead, in susceptible individuals, to a complex host-mediated inflammatory and immune response representing the primary etiological factor of periodontal damage that occurs in periodontitis. Periodontal disease is a chronic inflammatory condition affecting about 20-50% of people worldwide and manifesting clinically through the detection of gingival inflammation, clinical attachment loss (CAL), radiographic assessed resorption of alveolar bone, periodontal pockets, gingival bleeding upon probing, teeth mobility and their potential loss in advanced stages. This review will evaluate the changes characterizing the oral microbiota in healthy periodontal tissues and those affected by periodontal disease through the evidence present in the literature. An important focus will be placed on the immediate and future impact of these changes on the modulation of the dysbiotic oral microbiome and clinical management of periodontal disease.
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Stefano, M. D., Polizzi, A., Santonocito, S., Romano, A., Lombardi, T., & Isola, G. (2022). Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment. International Journal of Molecular Sciences, 23(9), 5142. https://doi.org/10.3390/ijms23095142
Stefano, Mattia Di, et al. "Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment." International Journal of Molecular Sciences, vol. 23, no. 9, 2022, pp. 5142, https://doi.org/10.3390/ijms23095142.
Stefano, Mattia Di, Alessandro Polizzi, Simona Santonocito, Alessandra Romano, Teresa Lombardi, and Gaetano Isola. "Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment." International Journal of Molecular Sciences 23, no. 9 (2022): 5142. https://doi.org/10.3390/ijms23095142.
Stefano M. D., Polizzi A., Santonocito S. [и др.] Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment // International Journal of Molecular Sciences. — 2022. — Vol. 23, № 9. — P. 5142. — URL: https://doi.org/10.3390/ijms23095142
@article{stefano2022impact,
title = {{Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment}},
author = {Mattia Di Stefano and Alessandro Polizzi and Simona Santonocito and Alessandra Romano and Teresa Lombardi and Gaetano Isola},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
number = {9},
pages = {5142},
doi = {10.3390/ijms23095142},
url = {https://doi.org/10.3390/ijms23095142}
}TY - JOUR AU - Stefano, Mattia Di AU - Polizzi, Alessandro AU - Santonocito, Simona AU - Romano, Alessandra AU - Lombardi, Teresa AU - Isola, Gaetano TI - Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment JO - International Journal of Molecular Sciences VL - 23 IS - 9 SP - 5142 PY - 2022 DA - 2022/05/05 DO - 10.3390/ijms23095142 UR - https://doi.org/10.3390/ijms23095142 ER -
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