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Yumei An, Sunao Li, Xinqi Huang, Xueshi Chen, Haiyan Shan, Mingyang Zhang
In the human body, copper is an important trace element and is a cofactor for several important enzymes involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis. Copper is also necessary for cellular processes, such as the regulation of intracellular signal transduction, catecholamine balance, myelination of neurons, and efficient synaptic transmission in the central nervous system. Copper is naturally present in some foods and is available as a dietary supplement. Only small amounts of copper are typically stored in the body and a large amount of copper is excreted through bile and urine. Given the critical role of copper in a breadth of cellular processes, local concentrations of copper and the cellular distribution of copper transporter proteins in the brain are important to maintain the steady state of the internal environment. The dysfunction of copper metabolism or regulatory pathways results in an imbalance in copper homeostasis in the brain, which can lead to a myriad of acute and chronic pathological effects on neurological function. It suggests a unique mechanism linking copper homeostasis and neuronal activation within the central nervous system. This article explores the relationship between impaired copper homeostasis and neuropathophysiological progress in brain diseases.
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An, Y., Li, S., Huang, X., Chen, X., Shan, H., & Zhang, M. (2022). The Role of Copper Homeostasis in Brain Disease. International Journal of Molecular Sciences, 23(22), 13850. https://doi.org/10.3390/ijms232213850
An, Yumei, et al. "The Role of Copper Homeostasis in Brain Disease." International Journal of Molecular Sciences, vol. 23, no. 22, 2022, pp. 13850, https://doi.org/10.3390/ijms232213850.
An, Yumei, Sunao Li, Xinqi Huang, Xueshi Chen, Haiyan Shan, and Mingyang Zhang. "The Role of Copper Homeostasis in Brain Disease." International Journal of Molecular Sciences 23, no. 22 (2022): 13850. https://doi.org/10.3390/ijms232213850.
An Y., Li S., Huang X. [и др.] The Role of Copper Homeostasis in Brain Disease // International Journal of Molecular Sciences. — 2022. — Vol. 23, № 22. — P. 13850. — URL: https://doi.org/10.3390/ijms232213850
@article{an2022role,
title = {{The Role of Copper Homeostasis in Brain Disease}},
author = {Yumei An and Sunao Li and Xinqi Huang and Xueshi Chen and Haiyan Shan and Mingyang Zhang},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
number = {22},
pages = {13850},
doi = {10.3390/ijms232213850},
url = {https://doi.org/10.3390/ijms232213850}
}TY - JOUR AU - An, Yumei AU - Li, Sunao AU - Huang, Xinqi AU - Chen, Xueshi AU - Shan, Haiyan AU - Zhang, Mingyang TI - The Role of Copper Homeostasis in Brain Disease JO - International Journal of Molecular Sciences VL - 23 IS - 22 SP - 13850 PY - 2022 DA - 2022/11/10 DO - 10.3390/ijms232213850 UR - https://doi.org/10.3390/ijms232213850 ER -
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