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Giuseppe Genchi, Graziantonio Lauria, Alessia Anna Catalano, Maria Stefania Sinicropi, Alessia Carocci
Selenium (Se) is a naturally occurring metalloid element essential to human and animal health in trace amounts but it is harmful in excess. Se plays a substantial role in the functioning of the human organism. It is incorporated into selenoproteins, thus supporting antioxidant defense systems. Selenoproteins participate in the metabolism of thyroid hormones, control reproductive functions and exert neuroprotective effects. Among the elements, Se has one of the narrowest ranges between dietary deficiency and toxic levels. Its level of toxicity may depend on chemical form, as inorganic and organic species have distinct biological properties. Over the last decades, optimization of population Se intake for the prevention of diseases related to Se deficiency or excess has been recognized as a pressing issue in modern healthcare worldwide. Low selenium status has been associated with an increased risk of mortality, poor immune function, cognitive decline, and thyroid dysfunction. On the other hand, Se concentrations slightly above its nutritional levels have been shown to have adverse effects on a broad spectrum of neurological functions and to increase the risk of type-2 diabetes. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important issue to elucidate its effect on human diseases. This review gives an overview of the role of Se in human health highlighting the effects of its deficiency and excess in the body. The biological activity of Se, mainly performed through selenoproteins, and its epigenetic effect is discussed. Moreover, a brief overview of selenium phytoremediation and rhizofiltration approaches is reported.
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Genchi, G., Lauria, G., Catalano, A. A., Sinicropi, M. S., & Carocci, A. (2023). Biological Activity of Selenium and Its Impact on Human Health. International Journal of Molecular Sciences, 24(3), 2633. https://doi.org/10.3390/ijms24032633
Genchi, Giuseppe, et al. "Biological Activity of Selenium and Its Impact on Human Health." International Journal of Molecular Sciences, vol. 24, no. 3, 2023, pp. 2633, https://doi.org/10.3390/ijms24032633.
Genchi, Giuseppe, Graziantonio Lauria, Alessia Anna Catalano, Maria Stefania Sinicropi, and Alessia Carocci. "Biological Activity of Selenium and Its Impact on Human Health." International Journal of Molecular Sciences 24, no. 3 (2023): 2633. https://doi.org/10.3390/ijms24032633.
Genchi G., Lauria G., Catalano A. A. [и др.] Biological Activity of Selenium and Its Impact on Human Health // International Journal of Molecular Sciences. — 2023. — Vol. 24, № 3. — P. 2633. — URL: https://doi.org/10.3390/ijms24032633
@article{genchi2023biological,
title = {{Biological Activity of Selenium and Its Impact on Human Health}},
author = {Giuseppe Genchi and Graziantonio Lauria and Alessia Anna Catalano and Maria Stefania Sinicropi and Alessia Carocci},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
number = {3},
pages = {2633},
doi = {10.3390/ijms24032633},
url = {https://doi.org/10.3390/ijms24032633}
}TY - JOUR AU - Genchi, Giuseppe AU - Lauria, Graziantonio AU - Catalano, Alessia Anna AU - Sinicropi, Maria Stefania AU - Carocci, Alessia TI - Biological Activity of Selenium and Its Impact on Human Health JO - International Journal of Molecular Sciences VL - 24 IS - 3 SP - 2633 PY - 2023 DA - 2023/01/30 DO - 10.3390/ijms24032633 UR - https://doi.org/10.3390/ijms24032633 ER -
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