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Maria Inês Costa, Ana Bela Sarmento‐Ribeiro, Ana Cristina Gonçalves
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson's disease, Alzheimer's disease, and other age-related diseases. This review focuses on Zn's roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases.
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Costa, M. I., Sarmento‐Ribeiro, A. B., & Gonçalves, A. C. (2023). Zinc: From Biological Functions to Therapeutic Potential. International Journal of Molecular Sciences, 24(5), 4822. https://doi.org/10.3390/ijms24054822
Costa, Maria Inês, et al. "Zinc: From Biological Functions to Therapeutic Potential." International Journal of Molecular Sciences, vol. 24, no. 5, 2023, pp. 4822, https://doi.org/10.3390/ijms24054822.
Costa, Maria Inês, Ana Bela Sarmento‐Ribeiro, and Ana Cristina Gonçalves. "Zinc: From Biological Functions to Therapeutic Potential." International Journal of Molecular Sciences 24, no. 5 (2023): 4822. https://doi.org/10.3390/ijms24054822.
Costa M. I., Sarmento‐Ribeiro A. B., Gonçalves A. C. Zinc: From Biological Functions to Therapeutic Potential // International Journal of Molecular Sciences. — 2023. — Vol. 24, № 5. — P. 4822. — URL: https://doi.org/10.3390/ijms24054822
@article{costa2023zinc,
title = {{Zinc: From Biological Functions to Therapeutic Potential}},
author = {Maria Inês Costa and Ana Bela Sarmento‐Ribeiro and Ana Cristina Gonçalves},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
number = {5},
pages = {4822},
doi = {10.3390/ijms24054822},
url = {https://doi.org/10.3390/ijms24054822}
}TY - JOUR AU - Costa, Maria Inês AU - Sarmento‐Ribeiro, Ana Bela AU - Gonçalves, Ana Cristina TI - Zinc: From Biological Functions to Therapeutic Potential JO - International Journal of Molecular Sciences VL - 24 IS - 5 SP - 4822 PY - 2023 DA - 2023/03/02 DO - 10.3390/ijms24054822 UR - https://doi.org/10.3390/ijms24054822 ER -
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