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David Lee, Tamara Minko
Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits the penetration of therapeutic molecules to the brain after oral or parenteral administration, which, in combination with hepatic metabolism and drug elimination and inactivation during its journey in the systemic circulation, decreases the efficacy of the treatment, requires high drug doses and often induces adverse side effects. Nose-to-brain drug delivery allows the direct transport of therapeutic molecules by bypassing the BBB and increases drug concentration in the brain. The present review describes mechanisms of nose-to-brain drug delivery and discusses recent advances in this area with especial emphasis on nanotechnology-based approaches.
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Lee, D., & Minko, T. (2021). Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier. Pharmaceutics, 13(12), 2049. https://doi.org/10.3390/pharmaceutics13122049
Lee, David, and Tamara Minko. "Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier." Pharmaceutics, vol. 13, no. 12, 2021, pp. 2049, https://doi.org/10.3390/pharmaceutics13122049.
Lee, David, and Tamara Minko. "Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier." Pharmaceutics 13, no. 12 (2021): 2049. https://doi.org/10.3390/pharmaceutics13122049.
Lee D., Minko T. Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier // Pharmaceutics. — 2021. — Vol. 13, № 12. — P. 2049. — URL: https://doi.org/10.3390/pharmaceutics13122049
@article{lee2021nanotherapeutics,
title = {{Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier}},
author = {David Lee and Tamara Minko},
journal = {Pharmaceutics},
year = {2021},
volume = {13},
number = {12},
pages = {2049},
doi = {10.3390/pharmaceutics13122049},
url = {https://doi.org/10.3390/pharmaceutics13122049}
}TY - JOUR AU - Lee, David AU - Minko, Tamara TI - Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier JO - Pharmaceutics VL - 13 IS - 12 SP - 2049 PY - 2021 DA - 2021/11/30 DO - 10.3390/pharmaceutics13122049 UR - https://doi.org/10.3390/pharmaceutics13122049 ER -
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