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Antonios Vlachopoulos, Georgia Karlioti, Evangelia D. Balla, Vasileios Daniilidis, Theocharis Kalamas, Myrika Stefanidou, Nikolaos D. Bikiaris, Evi Christodoulou, Ioanna Koumentakou, Evangelos Karavas, Dimitrios Ν. Bikiaris
The sustained release of pharmaceutical substances remains the most convenient way of drug delivery. Hence, a great variety of reports can be traced in the open literature associated with drug delivery systems (DDS). Specifically, the use of microparticle systems has received special attention during the past two decades. Polymeric microparticles (MPs) are acknowledged as very prevalent carriers toward an enhanced bio-distribution and bioavailability of both hydrophilic and lipophilic drug substances. Poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and their copolymers are among the most frequently used biodegradable polymers for encapsulated drugs. This review describes the current state-of-the-art research in the study of poly(lactic acid)/poly(lactic-co-glycolic acid) microparticles and PLA-copolymers with other aliphatic acids as drug delivery devices for increasing the efficiency of drug delivery, enhancing the release profile, and drug targeting of active pharmaceutical ingredients (API). Potential advances in generics and the constant discovery of therapeutic peptides will hopefully promote the success of microsphere technology.
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Vlachopoulos, A., Karlioti, G., Balla, E. D., Daniilidis, V., Kalamas, T., Stefanidou, M., Bikiaris, N. D., Christodoulou, E., Koumentakou, I., Karavas, E., & Bikiaris, D. Ν. (2022). Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances. Pharmaceutics, 14(2), 359. https://doi.org/10.3390/pharmaceutics14020359
Vlachopoulos, Antonios, et al. "Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances." Pharmaceutics, vol. 14, no. 2, 2022, pp. 359, https://doi.org/10.3390/pharmaceutics14020359.
Vlachopoulos, Antonios, Georgia Karlioti, Evangelia D. Balla, Vasileios Daniilidis, Theocharis Kalamas, Myrika Stefanidou, Nikolaos D. Bikiaris, et al. "Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances." Pharmaceutics 14, no. 2 (2022): 359. https://doi.org/10.3390/pharmaceutics14020359.
Vlachopoulos A., Karlioti G., Balla E. D. [и др.] Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances // Pharmaceutics. — 2022. — Vol. 14, № 2. — P. 359. — URL: https://doi.org/10.3390/pharmaceutics14020359
@article{vlachopoulos2022polylactic,
title = {{Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances}},
author = {Antonios Vlachopoulos and Georgia Karlioti and Evangelia D. Balla and Vasileios Daniilidis and Theocharis Kalamas and Myrika Stefanidou and Nikolaos D. Bikiaris and Evi Christodoulou and Ioanna Koumentakou and Evangelos Karavas and Dimitrios Ν. Bikiaris},
journal = {Pharmaceutics},
year = {2022},
volume = {14},
number = {2},
pages = {359},
doi = {10.3390/pharmaceutics14020359},
url = {https://doi.org/10.3390/pharmaceutics14020359}
}TY - JOUR AU - Vlachopoulos, Antonios AU - Karlioti, Georgia AU - Balla, Evangelia D. AU - Daniilidis, Vasileios AU - Kalamas, Theocharis AU - Stefanidou, Myrika AU - Bikiaris, Nikolaos D. AU - Christodoulou, Evi AU - Koumentakou, Ioanna AU - Karavas, Evangelos AU - Bikiaris, Dimitrios Ν. TI - Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances JO - Pharmaceutics VL - 14 IS - 2 SP - 359 PY - 2022 DA - 2022/02/04 DO - 10.3390/pharmaceutics14020359 UR - https://doi.org/10.3390/pharmaceutics14020359 ER -
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