One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Sakshi V. Khairnar, Pritha Pagare, Aditya Thakre, Aswathy Rajeevan Nambiar, Vijayabhaskarreddy Junnuthula, Manju Cheripelil Abraham, Praveen Kolimi, Dinesh Nyavanandi, Sathish Dyawanapelly
Solid lipid nanoparticles (SLNs) are an alternate carrier system to liposomes, polymeric nanoparticles, and inorganic carriers. SLNs have attracted increasing attention in recent years for delivering drugs, nucleic acids, proteins, peptides, nutraceuticals, and cosmetics. These nanocarriers have attracted industrial attention due to their ease of preparation, physicochemical stability, and scalability. These characteristics make SLNs attractive for manufacture on a large scale. Currently, several products with SLNs are in clinical trials, and there is a high possibility that SLN carriers will quickly increase their presence in the market. A large-scale manufacturing unit is required for commercial applications to prepare enough formulations for clinical studies. Furthermore, continuous processing is becoming more popular in the pharmaceutical sector to reduce product batch-to-batch differences. This review paper discusses some conventional methods and the rationale for large-scale production. It further covers recent progress in scale-up methods for the synthesis of SLNs, including high-pressure homogenization (HPH), hot melt extrusion coupled with HPH, microchannels, nanoprecipitation using static mixers, and microemulsion-based methods. These scale-up technologies enable the possibility of commercialization of SLNs. Furthermore, ongoing studies indicate that these technologies will eventually reach the pharmaceutical market.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Khairnar, S. V., Pagare, P., Thakre, A., Nambiar, A. R., Junnuthula, V., Abraham, M. C., Kolimi, P., Nyavanandi, D., & Dyawanapelly, S. (2022). Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles. Pharmaceutics, 14(9), 1886. https://doi.org/10.3390/pharmaceutics14091886
Khairnar, Sakshi V., et al. "Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles." Pharmaceutics, vol. 14, no. 9, 2022, pp. 1886, https://doi.org/10.3390/pharmaceutics14091886.
Khairnar, Sakshi V., Pritha Pagare, Aditya Thakre, Aswathy Rajeevan Nambiar, Vijayabhaskarreddy Junnuthula, Manju Cheripelil Abraham, Praveen Kolimi, Dinesh Nyavanandi, and Sathish Dyawanapelly. "Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles." Pharmaceutics 14, no. 9 (2022): 1886. https://doi.org/10.3390/pharmaceutics14091886.
Khairnar S. V., Pagare P., Thakre A. [и др.] Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles // Pharmaceutics. — 2022. — Vol. 14, № 9. — P. 1886. — URL: https://doi.org/10.3390/pharmaceutics14091886
@article{khairnar2022review,
title = {{Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles}},
author = {Sakshi V. Khairnar and Pritha Pagare and Aditya Thakre and Aswathy Rajeevan Nambiar and Vijayabhaskarreddy Junnuthula and Manju Cheripelil Abraham and Praveen Kolimi and Dinesh Nyavanandi and Sathish Dyawanapelly},
journal = {Pharmaceutics},
year = {2022},
volume = {14},
number = {9},
pages = {1886},
doi = {10.3390/pharmaceutics14091886},
url = {https://doi.org/10.3390/pharmaceutics14091886}
}TY - JOUR AU - Khairnar, Sakshi V. AU - Pagare, Pritha AU - Thakre, Aditya AU - Nambiar, Aswathy Rajeevan AU - Junnuthula, Vijayabhaskarreddy AU - Abraham, Manju Cheripelil AU - Kolimi, Praveen AU - Nyavanandi, Dinesh AU - Dyawanapelly, Sathish TI - Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles JO - Pharmaceutics VL - 14 IS - 9 SP - 1886 PY - 2022 DA - 2022/09/06 DO - 10.3390/pharmaceutics14091886 UR - https://doi.org/10.3390/pharmaceutics14091886 ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.