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Victor Hmingthansanga, Nidhi Singh, Superna Banerjee, Sivakumar Manickam, V. Ravichandiran, Subramanian Natesan
The delivery of drugs via transdermal routes is an attractive approach due to ease of administration, bypassing of the first-pass metabolism, and the large skin surface area. However, a major drawback is an inability to surmount the skin's stratum corneum (SC) layer. Therefore, techniques reversibly modifying the stratum corneum have been a classical approach. Surmounting the significant barrier properties of the skin in a well-organised, momentary, and harmless approach is still challenging. Chemical permeation enhancers (CPEs) with higher activity are associated with certain side effects restricting their advancement in transdermal drug delivery. Furthermore, complexity in the interaction of CPEs with the skin has led to difficulty in elucidating the mechanism of action. Nevertheless, CPEs-aided transdermal drug delivery will accomplish its full potential due to advancements in analytical techniques, synthetic chemistry, and combinatorial studies. This review focused on techniques such as drug-vehicle interaction, vesicles and their analogues, and novel CPEs such as lipid synthesis inhibitors (LSIs), cell-penetrating peptides (CPPs), and ionic liquids (ILs). In addition, different types of microneedles, including 3D-printed microneedles, have been focused on in this review.
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Hmingthansanga, V., Singh, N., Banerjee, S., Manickam, S., Ravichandiran, V., & Natesan, S. (2022). Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches. Pharmaceutics, 14(12), 2818. https://doi.org/10.3390/pharmaceutics14122818
Hmingthansanga, Victor, et al. "Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches." Pharmaceutics, vol. 14, no. 12, 2022, pp. 2818, https://doi.org/10.3390/pharmaceutics14122818.
Hmingthansanga, Victor, Nidhi Singh, Superna Banerjee, Sivakumar Manickam, V. Ravichandiran, and Subramanian Natesan. "Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches." Pharmaceutics 14, no. 12 (2022): 2818. https://doi.org/10.3390/pharmaceutics14122818.
Hmingthansanga V., Singh N., Banerjee S. [и др.] Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches // Pharmaceutics. — 2022. — Vol. 14, № 12. — P. 2818. — URL: https://doi.org/10.3390/pharmaceutics14122818
@article{hmingthansanga2022improved,
title = {{Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches}},
author = {Victor Hmingthansanga and Nidhi Singh and Superna Banerjee and Sivakumar Manickam and V. Ravichandiran and Subramanian Natesan},
journal = {Pharmaceutics},
year = {2022},
volume = {14},
number = {12},
pages = {2818},
doi = {10.3390/pharmaceutics14122818},
url = {https://doi.org/10.3390/pharmaceutics14122818}
}TY - JOUR AU - Hmingthansanga, Victor AU - Singh, Nidhi AU - Banerjee, Superna AU - Manickam, Sivakumar AU - Ravichandiran, V. AU - Natesan, Subramanian TI - Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches JO - Pharmaceutics VL - 14 IS - 12 SP - 2818 PY - 2022 DA - 2022/12/15 DO - 10.3390/pharmaceutics14122818 UR - https://doi.org/10.3390/pharmaceutics14122818 ER -
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