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Jie Lou, Hongli Duan, Qin Qin, Zhipeng Teng, Fengxu Gan, Xiaofang Zhou, Xiaofang Zhou, Xing Zhou, Xing Zhou
The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and targeted design of oral drug delivery system. Innovative pharmaceutical approaches including nanoparticulate formulations, biomimetic drug formulations, and microfabricated devices have been explored to optimize drug targeting and bioavailability. In this review, the anatomical factors, biochemical factors, and physiology factors that influence delivering drug via oral route are discussed and recent advance in conventional and novel oral drug delivery approaches for improving drug bioavailability and targeting ability are highlighted. We also address the challenges and opportunities of oral drug delivery systems in future.
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Lou, J., Duan, H., Qin, Q., Teng, Z., Gan, F., Zhou, X., Zhou, X., Zhou, X., & Zhou, X. (2023). Advances in Oral Drug Delivery Systems: Challenges and Opportunities. Pharmaceutics, 15(2), 484. https://doi.org/10.3390/pharmaceutics15020484
Lou, Jie, et al. "Advances in Oral Drug Delivery Systems: Challenges and Opportunities." Pharmaceutics, vol. 15, no. 2, 2023, pp. 484, https://doi.org/10.3390/pharmaceutics15020484.
Lou, Jie, Hongli Duan, Qin Qin, Zhipeng Teng, Fengxu Gan, Xiaofang Zhou, Xiaofang Zhou, Xing Zhou, and Xing Zhou. "Advances in Oral Drug Delivery Systems: Challenges and Opportunities." Pharmaceutics 15, no. 2 (2023): 484. https://doi.org/10.3390/pharmaceutics15020484.
Lou J., Duan H., Qin Q. [и др.] Advances in Oral Drug Delivery Systems: Challenges and Opportunities // Pharmaceutics. — 2023. — Vol. 15, № 2. — P. 484. — URL: https://doi.org/10.3390/pharmaceutics15020484
@article{lou2023advances,
title = {{Advances in Oral Drug Delivery Systems: Challenges and Opportunities}},
author = {Jie Lou and Hongli Duan and Qin Qin and Zhipeng Teng and Fengxu Gan and Xiaofang Zhou and Xiaofang Zhou and Xing Zhou and Xing Zhou},
journal = {Pharmaceutics},
year = {2023},
volume = {15},
number = {2},
pages = {484},
doi = {10.3390/pharmaceutics15020484},
url = {https://doi.org/10.3390/pharmaceutics15020484}
}TY - JOUR AU - Lou, Jie AU - Duan, Hongli AU - Qin, Qin AU - Teng, Zhipeng AU - Gan, Fengxu AU - Zhou, Xiaofang AU - Zhou, Xiaofang AU - Zhou, Xing AU - Zhou, Xing TI - Advances in Oral Drug Delivery Systems: Challenges and Opportunities JO - Pharmaceutics VL - 15 IS - 2 SP - 484 PY - 2023 DA - 2023/02/01 DO - 10.3390/pharmaceutics15020484 UR - https://doi.org/10.3390/pharmaceutics15020484 ER -
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