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Cláudia Viegas, Ana B. Patrício, João Prata, Akhtar Nadhman, Pavan Kumar Chintamaneni, Pedro Fonte
Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.
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Viegas, C., Patrício, A. B., Prata, J., Nadhman, A., Chintamaneni, P. K., & Fonte, P. (2023). Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review. Pharmaceutics, 15(6), 1593. https://doi.org/10.3390/pharmaceutics15061593
Viegas, Cláudia, et al. "Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review." Pharmaceutics, vol. 15, no. 6, 2023, pp. 1593, https://doi.org/10.3390/pharmaceutics15061593.
Viegas, Cláudia, Ana B. Patrício, João Prata, Akhtar Nadhman, Pavan Kumar Chintamaneni, and Pedro Fonte. "Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review." Pharmaceutics 15, no. 6 (2023): 1593. https://doi.org/10.3390/pharmaceutics15061593.
Viegas C., Patrício A. B., Prata J. [и др.] Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review // Pharmaceutics. — 2023. — Vol. 15, № 6. — P. 1593. — URL: https://doi.org/10.3390/pharmaceutics15061593
@article{viegas2023solid,
title = {{Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review}},
author = {Cláudia Viegas and Ana B. Patrício and João Prata and Akhtar Nadhman and Pavan Kumar Chintamaneni and Pedro Fonte},
journal = {Pharmaceutics},
year = {2023},
volume = {15},
number = {6},
pages = {1593},
doi = {10.3390/pharmaceutics15061593},
url = {https://doi.org/10.3390/pharmaceutics15061593}
}TY - JOUR AU - Viegas, Cláudia AU - Patrício, Ana B. AU - Prata, João AU - Nadhman, Akhtar AU - Chintamaneni, Pavan Kumar AU - Fonte, Pedro TI - Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review JO - Pharmaceutics VL - 15 IS - 6 SP - 1593 PY - 2023 DA - 2023/05/25 DO - 10.3390/pharmaceutics15061593 UR - https://doi.org/10.3390/pharmaceutics15061593 ER -
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